食管鳞癌中COX-2和VEGF的表达与放疗疗效和预后的关系  

Expression of COX-2 and VEGF in esophageal squamous cell carcinoma and its relationship with radiotherapy effect and prognosis

作　　者：朱兆峰[1] 卢鑫[1] 

机构地区：[1]泰安市肿瘤防治院放疗科,山东泰安271000

出　　处：《实用肿瘤杂志》2013年第3期261-264,共4页Journal of Practical Oncology

基　　金：泰安市科技发展计划项目(No.20103061)

摘　　要：目的探讨环氧合酶-2(COX-2)和血管内皮生长因子(VEGF)与食管鳞癌患者放疗疗效和预后的关系。方法 60例食管鳞癌患者行局部放疗,并应用免疫组织化学方法检测放疗前组织COX-2和VEGF的表达情况,分析两者的表达与放疗疗效和预后的关系。结果 60例食管鳞癌患者中COX-2和VEGF的表达呈显著正相关。两者表达均阴性者放疗有效率较高,分别为94.7%和100.0%,且生存率亦高于阳性表达者。结论 COX-2和VEGF阳性表达的患者放疗疗效差,生存期短。两者联合检测可作为食管癌患者放疗后预后不良的指标。Objective To explore the expression of COX-2 and VEGF in esophageal squamous cell carcinoma and its relationship with radiotherapy effect and prognosis. Methods Sixty patients with esophageal squamous cell carcinoma received radiotherapy,and the expressions of COX-2 and VEGF were detected by S-P immunohistoehemieal method, the relationship between the expressions and radiotherapy effect and prognosis was analyzed. Results The expression of COX-2 and VEGF was positively correlative,the radiotherapy effective rate of both COX-2 and VEGF negative group （94.7% and 100.0% , respectively） was higher than that of COX-2 and VEGF positive group, and the survival rate was also higher. Conclusions The radiotherapy effect of patients with positive expression of COX-2 and VEGF was bad, and the survival time was short. Detection of expression of both COX-2 and VEGF was important referencing index to reflect the radiotherapy effect and prognosis for esophageal carcinoma.

关 键 词：食管肿瘤 癌 鳞状细胞 环氧合酶-2 血管内皮生长因子 放射治疗 预后 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]