镉系量子点细胞毒性的研究进展  

Cytotoxicity of cadmium-based quantum dots

作　　者：李晓明[1] 陈楠[1] 苏媛媛[2] 何耀[2] 樊春海[1] 黄庆[1] 

机构地区：[1]中国科学院上海应用物理研究所物理生物实验室,上海201800 [2]苏州大学功能纳米与软物质研究院(FUNSON),苏州215123

出　　处：《科学通报》2013年第15期1393-1402,共10页Chinese Science Bulletin

基　　金：国家自然科学基金(10975179;11179004);国家重点基础研究发展计划(2012CB825805)资助

摘　　要：量子点是一种具有优良荧光性能的新型纳米材料,在生物医学领域具有广泛的应用前景.随着量子点在生物学中逐渐被应用,生物相容性问题已成为制约其临床应用的瓶颈,因而受到了广泛的关注.目前的研究结果显示,量子点的细胞毒性不仅与其本身的制备方法及表面性质、粒径大小等理化性质相关,而且受到测试细胞的类型、处理环境和给药方式等多种因素的影响.本文针对光学性能优异的镉系量子点,对其制备方式和应用前景进行了简述,并根据本实验室近年来在水相合成量子点的细胞毒性研究方面取得的一系列结果,分析了镉系量子点细胞毒性的复杂机制,提出镉系量子点的细胞毒性很大程度上来源于解离或存在于表面的镉离子,而量子点的纳米效应及其在细胞内的分布也极大地影响了其细胞毒性.Semiconductor quantum dots（QDs） possess superior optical properties and show great potential for use in biological and biomedical applications.However,there are increasing concerns regarding the assessment of their cytotoxicity,and their biocompatibility currently limits their use in further clinical applications.Recent results indicate that QD cytotoxicity is closely associated with the QDs＇ physical and chemical properties such as particle size and surface properties.On the other hand,results have also shown that toxicity varies in different cell lines and is affected by other factors.In this review,we summarize the recent results obtained in our laboratory on the cytotoxicity of aqueous synthetic cadmium-based QDs.We propose that the released cadmium ions contribute to a large extent to the cytotoxicity of cadmium-based QDs,and that the nano-effects and intracellular distributions of QDs also greatly affect their cytotoxicity.

关 键 词：镉系量子点 表面性质 细胞毒性 镉离子 

分 类 号：O471.1[理学—半导体物理]