PPARγ及上皮-间质转化与肿瘤的关系  

Peroxisome proliferator-activated receptor gamma and epithelial-mesenchymal transition in cancer

作　　者：高超[1] 冯向营[1] 

机构地区：[1]大连大学附属新华医院神经内一科,大连116021

出　　处：《国际肿瘤学杂志》2013年第6期425-428,共4页Journal of International Oncology

摘　　要：肿瘤发生上皮-间质转化（EMT）后侵袭和转移能力明显增强，是肿瘤患者治疗失败的原因之一。过氧化物酶增殖激活受体γ（PPARγ）是EMT的重要调节因子。研究提示，PPARγ激活后能通过调节E-钙黏蛋白、Smad复合体、机体微环境等影响肿瘤EMT的发生发展。因此，深人研究PPARl及EMT与肿瘤的关系有望为肿瘤治疗提供新的方向。Epithelial-mesenchymal transition （EMT） of cancer can enhance the abilities of invasion and metastasis of cancer cells, which is one of the reasons for treatment failure. Peroxisome proliferator-activa- ted receptor gamma （PPARγ） is an important regulatory factor in EMT of cancer cells. Recent researches show that activation of PPARγ plays a role in the occurrence and development of EMT by regulating the E-cadherin, Smad complex and body microenvironment. Therefore, in-depth research for the relationship among PPARγ, EMT and cancer is expected to provide a new direction for tumor treatment.

关 键 词：PPARΓ 肿瘤 SMAD蛋白质类 E-钙黏蛋白 

分 类 号：R730[医药卫生—肿瘤]