光敏剂药物运载体系在光动力治疗肿瘤中的应用  

Application of photosensitizer drug delivery system in photodynamic therapy of tumors

作　　者：涂庆峰[1] 王秀丽[1] 石磊[1] 王宏伟[2] 

机构地区：[1]安徽医科大学上海皮肤病临床学院暨上海市皮肤病医院光医学治疗科,安徽200050 [2]复旦大学附属华东医院皮肤科

出　　处：《国际肿瘤学杂志》2013年第6期469-471,共3页Journal of International Oncology

基　　金：上海市自然科学基金（11ZRl432800）;上海市卫生系统优秀人才培养计划（XBFt2011059）

摘　　要：诸多体内外实验证明，通过运用适宜的药物运载体系既可以增加光敏剂的稳定性，也可以促进光敏剂在肿瘤组织中聚集，提高光动力治疗的靶向性，加深其作用深度和单态氧的产出率，并能减少不良反应。所以新型光敏剂药物运载体系的研究在光动力治疗肿瘤中拥有重要的应用价值。In vitro or in vivo results of investigations into the development of photosensitizer drug deliv- ery systems have demonstrated that the use of vehicles not only enhance the stability of photosensitizer, but also promote the accumulation of photosensitizer in tumor tissue, enhance the targetability of photodynamic therapy, the working depth, the yield of singlet oxygen and overcome many untoward effects. So the research of new pho- tosensitizer drug delivery system has important application value in photodynamic therapy of tumor.

关 键 词：光动力疗法 光敏感药 药物载体 肿瘤 

分 类 号：R730[医药卫生—肿瘤]