树豆脂溶性部位对糖尿病和肥胖小鼠骨密度及血脂水平的影响  

Effects of hydrophobic fraction of Cajanus cajan(L.) Millspaugh on bone density and blood lipid level in obese and diabetic mice

作　　者：叶贵福[1] 王璐[1] 杨瑞仪[1] 田汝华[1] 胡英杰[1] 沈小玲[1] 

机构地区：[1]广州中医药大学热带医学研究所中药新药发现实验室,广东广州510405

出　　处：《中国药理学通报》2013年第7期961-965,共5页Chinese Pharmacological Bulletin

基　　金：国家"重大新药创制"科技重大专项资助项目(No2009ZX09103-436)

摘　　要：目的探讨树豆脂溶性部位(SDE)对糖尿病和肥胖小鼠骨密度及血脂水平的影响。方法 db/db先天糖尿病小鼠和ob/ob先天肥胖小鼠连续8周灌服SDE后,进行骨密度、血清碱性磷酸酶(ALP)、血钙(Ca2+)及血脂水平测定。结果与灌服溶剂空白的模型组小鼠相比,(1)灌服SDE的db/db和ob/ob小鼠胫骨骨密度明显增加(P<0.05),血清ALP水平明显下降(P<0.01),但血钙水平无明显改变;(2)灌服SDE的db/db小鼠血脂水平无明显变化,灌服SDE的ob/ob小鼠血清甘油三酯(TG)水平明显下降(P<0.05),血清总胆固醇(TC)和血清低密度脂蛋白胆固醇(LDL-C)水平明显下降(P<0.01)。结论 SDE能提高糖尿病和肥胖小鼠骨密度,并能改善肥胖小鼠的血脂代谢。Aim To investigate the effect of hydropho- bic fraction of Cajanus cajan （ L. ） Millspaugh （SDE） on bone density and blood lipid level in diabetic and obese mice. Methods The db/db congenital diabetic mice and ob/ob congenital obese mice were orally ad- ministered with SDE for 8 weeks, bone density as well as serum TG, TC, LDL-C, HDL-C, ALP and Ca2＋ were measured. Results Compared to mice treated with vehicle, （1） SDE-treated db/db and ob/ob mice had greater bone density （P 〈 0. 05 ） and lower serum ALP level （P 〈0.01 ） , with serum Ca2＋ level relative- ly unchanged; （2） SDE-treated db/db mice had rela- tively unchanged blood lipid level, but SDE-treated ob/ob mice had significantly lower levels of TG （P 〈 0.05）, TC （P 〈0.01） and LDL-C （P 〈0.01）. Conclusion SDE increased bone density in diabetic and obese mice, and improved lipid metabolism in obese mice.

关 键 词：树豆 糖尿病 肥胖 骨质疏松 骨密度 血脂 

分 类 号：R-332[医药卫生] R284.1