滇产玉米须化学成分研究  

Chemical constituents of the style of Zea mays L.from Yunnan

作　　者：赵冕[1] 刘传水[1] 尹田鹏[1] 方海仙[1] 蔡乐[1] 丁中涛[1] 

机构地区：[1]教育部自然资源药物化学重点实验室,云南大学化学科学与工程学院,云南昆明650091

出　　处：《化学研究与应用》2013年第6期846-850,共5页Chemical Research and Application

基　　金：2013-01-19基金项目:云南大学"中青年骨干教师培养计划"专项经费项目资助;云南省教育厅研究基金项目(08Y0038)资助;教育部自然资源药物化学重点实验室开放基金项目(2009102204)资助

摘　　要：为研究滇产玉米须中的化学成分,采用硅胶柱层析和Sephadex LH-20柱层析进行化合物分离和纯化,采用EI-MS、HR-ESI-MS、1D-和2D-NMR以及化学方法对化合物结构进行鉴定。从滇产玉米须中分离得到了4个化合物,分别鉴定为:(2S,3S,4R)-2-[(2'R)-2'-hydroxydocosanoylamino]-1,3,4-octadecanetriol(1),ent-rosa-ne-5β,15,16-triol(2),麦角甾-7,22-二烯-3β,5α,6β-三醇(3),豆甾-5-烯-3β,7α-二醇(4)。化合物1和2为首次从玉米须中分离得到,并采用化学方法对化合物1进行结构确证,采用2D-NMR对这化合物2和3的碳氢数据进行准确归属。To study the chemical constituents of the style of Zea mays, silica gel and Sephadex LH-20 column chromatography was applied to separate and purify the compounds from the style of Zea mays. EIMS, HRESIMS 1 D-and 2D-NMR spectra was adopted to determine the structure of the compounds. Four compounds were isolated and their structures were elucidated as：（2S, 3S,4R）-2- [ （2＇R） -2＇-hydroxydocosanoylamino ] -1,3,4-octadecanetriol （ 1 ）, ent-rosane-5β、3, 15,16-triol （ 2）, asergosta-7,22-dien-3β,5 or, 6β- triol（3） ,and stigmasta-5-en-3/3,7α-diol（4）. Compound 1 and 2 were isolated from this plant for the first time. The structure of 1 was determined on the basis of methanolysis. The proton and carbon signals of 2 and 3 were assigned by 2D-NMR techniques.

关 键 词：玉米须 二萜 脑苷脂 结构解析 

分 类 号：R284.1[医药卫生—中药学]