氨磺必利与奥氮平治疗急性期精神分裂症的疗效分析  

The curative effects of amisulpride and olanzapine on acute schizophrenia

作　　者：孙霞[1,2] 杨建立[1] 

机构地区：[1]天津医科大学研究生院,天津300222 [2]天津市安定医院三科

出　　处：《中国慢性病预防与控制》2013年第3期292-293,296,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的比较氨磺必利和奥氮平治疗急性精神分裂症的疗效和安全性。方法 74例精神分裂症患者被随机分为氨磺必利组(38例)和奥氮平组(36例)。分别于基线和治疗6周后进行阳性与阴性症状量表(PANSS)评分,测定空腹血糖、血脂、血清泌乳素和心电图检查。记录不良反应。结果治疗6周后,2组患者PANSS总分均较基线时明显降低,差异有统计学意义(t值分别为22.16、22.23,P<0.01);氨磺必利组减分为(32.4±15.8)分,奥氮平组为(35.6±13.9)分;2组间差异无统计学意义(t=0.78,P>0.05)。2组治疗后有效率(分别为86.8%、88.9%)差异无统计学意义(P>0.05)。治疗6周后氨磺必利组泌乳素水平较基线时明显增加,差异有统计学意义(t=-3.3,P<0.05),奥氮平组血脂、血糖水平较基线时明显增高,差异均有统计学意义(t=8.82、9.23,P<0.01)。氨磺必利组主要不良反应为停经、溢乳、锥体外系不良反应(EPS)、失眠、下肢痛;奥氮平组主要不良反应为体重增加、体位性低血压、嗜睡。结论氨磺必利治疗急性精神分裂症疗效与奥氮平相当;对泌乳素有影响,较少引起嗜睡及代谢异常。Objective To evaluate the curative effects and safety of amisulpride and olanzapine on acute schizophrenia. Methods Seventy four patients with acute schizophrenia were divided into amisulpride group （n=38） and olanzapine group （n=36）. Before and after treatment for 6 months, Positive and Negative Syndrome Scale （PANSS） was used to score for all patients, the blood sugar, blood lipid, serum prolactin （PRL） and electrocardiogram （ECG） were examined. Results After treatment for 6 months, the total scores of PANSS in two groups were significantly lower than the baseline levels （P〈0.01）, but there was no significant difference of total scores between two groups. The effective rates of two groups were 86.8% and 88.9%, respectively, there was no significant difference. After treatment for 6 months, the PRL level of amisulpride group was significantly higher than the baseline level （P〈0.05）, the blood sugar and blood lipid levels of olanzapine group were significantly higher than the baseline levels （P〈 0.01）. The main adverse effects in amisulpride group were menopause, galaetorrhea, EPS, insomnia and leg-pain. The main adverse effects in olanzapine group were weight-gain, low blood pressure and somnolence. Conclusion The curative effect of amisulpride and olanzapine on acute schizophrenia was similar to the curative effect of olanzapine, but amisulpride could impact PRL level and induce less somnolence and metabolic abnormalities.

关 键 词：氨磺必利 奥氮平 精神分裂症 疗效 安全性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]