经尿道电切联合沙培林黏膜下注射治疗浅表性膀胱肿瘤的临床研究  

The clinical efficacy on treatment of bladder cancer and transurethral injection of OK - 432

作　　者：汪前亮[1] 杨嗣星[1] 吴天鹏[1] 钱辉军[1] 张孝斌[1] 程帆[1] 刘凌琪[1] 宋超[1] 郑府[1] 

机构地区：[1]武汉大学人民医院,湖北430060

出　　处：《国际泌尿系统杂志》2013年第3期296-298,共3页International Journal of Urology and Nephrology

摘　　要：目的探讨经尿道膀胱肿瘤电切术联合沙培林膀胱黏膜下注射治疗浅表性膀胱肿瘤的疗效。方法将85例膀胱肿瘤患者分为两组（A组和B组），A组42例，B组43例，两组均行经尿道膀胱肿瘤电切术，A组另用5KE沙培林溶于50m10．9％Nacl溶液行膀胱黏膜下注射。两组术后均行沙培林膀胱灌注，膀胱内灌注保留2h，每周1次，连续8周，以后每月灌一次，连续10个月。根据随访结果对两种方法的疗效进行评价。结果A组平均随访24个月，B组平均随访26个月。A组随访期内复发4例（9．52％），B组随访期内复发16例（37．2％），A组复发率与B组比较，差异有统计学意义（P〈0．05）。结论经尿道电切联合沙培林黏膜下注射可减少膀胱肿瘤复发，操作简单，安全有效。Objectives To investigate the efficacy by studying electrovaporization of bladder cancer and transurethral injeetan of OK - 432. Methods 42 case of bladder cancer received the OK - 432 solution injected to the pediele of bladder tumor after operation, and 43 cases only received operation, do not give the OK -432 solution injected to the pedicle of bladder tumor. Both groups received OK -432 routine treatment, the effects Were evaluated according to recurrence ratio. Results Injection group had a mean follow - up of 24 months, control group had mean follow-up of 26 months, The recurrence rate of injection group was 9.52% （4/42） , and that of the control group was 37.2 （ 16/43 ）. There is a very significant difference between the two groups（ P 〈 0.05 ）. Conclusions Operation combined with OK -432 injection are simple and safe for the treatment of superficial bladder cancer, can increase the efficacy, and reduce recurren rate.

关 键 词：膀胱肿瘤 电外科手术 

分 类 号：R737.14[医药卫生—肿瘤]