不对称小分子催化合成的最新进展及其在药物合成中的应用  

Recent progress in asymmetric organocatalysis and its applications in drug synthesis

作　　者：董晓阳[1] 王子昱[1] 王永超[1] 戴振亚[1] 尤启冬[1] 

机构地区：[1]中国药科大学江苏省药物分子设计与成药性优化重点实验室,南京210009

出　　处：《中国药科大学学报》2013年第3期193-201,共9页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.21102180)~~

摘　　要：近年来,数以千计新型手性小分子催化剂的出现为不对称催化开辟了新的通道和途径,尤其在手性药物中间体的合成中也发挥了巨大的作用,为新药的合成提供了新方法。本文基于手性小分子催化剂与底物的结合方式,对目前的手性小分子催化反应进行了总结和分类,阐述了手性小分子催化的最新进展以及目前手性小分子催化在药物合成中的应用,进而更好地研究和探索手性小分子催化合成。In the past decade, thousands of chiral organocatalysts have emerged for asymmetric synthesis, and opened up new channels and shortcuts, especially in the synthesis of chiral drug intermediates. They play an important role in developing new methods for the synthesis of new drugs. In these review, chiral organocatalytic reactions are summarized and classified based on the interaction manner way between chiral organocayalysts and substrates. The latest developments of organocatalysis and their applications in drug synthesis are present herein- after for exploring and developing better organocatalysis.

关 键 词：不对称小分子催化 不对称催化 不对称合成 手性药物中间体 

分 类 号：R914.5[医药卫生—药物化学]