不伴感染的急性卒中患者血清降钙素原水平的影响因素：回顾性病例系列研究  

Influencing factors of serum procalcitonin level in non-infected patients with acute stroke： a retrospective case series study

作　　者：林镇洲[1] 吴永明[1] 姬仲[1] 王胜男[1] 黄凯滨[1] 冀雅彬[1] 吴齐恒[1] 潘速跃[1] 

机构地区：[1]南方医科大学南方医院神经内科,广州510515

出　　处：《国际脑血管病杂志》2013年第4期271-276,共6页International Journal of Cerebrovascular Diseases

摘　　要：目的探讨不伴感染的急性卒中患者血清降钙素原（procalcitonin，PCT）水平的影响因素，为进一步探讨血清PCT预测急性卒中后感染提供依据。方法回顾性分析不伴感染的急性卒中患者的病历资料。根据基线血清PCT水平分为PCT增高组（〉0．05ng／ml）和PCT正常组（≤0．05ng／m1），比较两组间人口统计学和基线临床资料。应用多变量logistic回归分析确定不伴感染的急性卒中患者血清PCT水平的独立影响因素。结果共纳入发病24h内的非感染急性卒中患者61例，PCT增高组32例（52．5％），PCT正常组29例（47．5％）。PCT增高组基线C-反应蛋白（C-reactiveprotein，CRP）水平显著高于PCT正常组[（7．331±10．648）mg／L对（2．382±2．190）mg／L；t=-3．388，P=0．001]，但并未在多变量logistic回归分析中显示出统计学意义。两组患者其他人口统计学和基线临床资料方面均无显著性差异。结论在不伴感染的急性卒中患者中，人口统计学和基线临床资料均对PCT水平无影响，提示采用PCT预测急性卒中后感染时，可能不需要考虑人口统计学和基线临床资料对PCT的影响。Objective To investigate the influencing factors of serum procalcitonin （PCT） level in non- infected patients with acute stroke and to provide the basis for further investigation of serum PCT predicting post-stroke infection. Methods The medical records of the non-infected patients with acute stroke were analyzed retrospectively. According to the baseline serum PCT levels, the patients were divided into either an increased PCT group （ 〉 0. 05 ng/ml） or a normal PCT goup （ ≤ 0. 05 ng/ml）. Then the demographic and baseline clinical data between the two groups were compared. Multivariate logistic regression analysis was used to identify the independent influencing factors of serum PCT level in the non-infected patients with acute stroke. Results A total of 61 non-infected patients with acute stroke within 24 h of onset were enrolled in the study, 32 （52. 5%） were in the increased PCT group and 29 （47. 5%） were in the normal PCT group. The baseline C-reactive protein （CLIP） level in the increased PCT group was significantly higher than that in the normal PCT group （7. 331 ± 10. 648 mg/L vs. 2. 382 ±2. 190 rag/L; t = -3.388, P =0. 001）, but there was no significant difference in the multivariate logistic regression analysis. There were no significant differences in other demographic and baseline clinical data between the two groups. Conclusions In the non-infeeted patients with acute stroke, the demographic and baseline clinical data have no influence on PCT level, suggesting that it may not need to consider the influence of the demographic and baseline clinical data when PCT is used for predicting post-stroke infection.

关 键 词：卒中 降钙素原 C反应蛋白 感染 

分 类 号：R743.3[医药卫生—神经病学与精神病学]