N端脑钠肽原与缺血性卒中  

N-Terminal pro-brain natriuretic peptide and ischenfic stroke

作　　者：孔艳艳[1] 刘楠[2] 姜新[2] 陈晓虹[2] 

机构地区：[1]大连医科大学研究生院,大连116044 [2]辽宁省人民医院神经内科,沈阳110016

出　　处：《国际脑血管病杂志》2013年第4期305-309,共5页International Journal of Cerebrovascular Diseases

基　　金：辽宁省医学高峰建设资助项目（辽卫[2010]）

摘　　要：脑钠肽（brain natriuretic peptide，BNP）是心功能紊乱时最敏感和特异的实验室指标之一。N端脑钠肽原（N-terminal pro-brain natriuretic peptide，NT-proBNP）是BNP的N端前体，两者的功能并不完全一致，但其理化性质优于BNP，现已广泛用于心血管疾病的诊断和治疗监测。在卒中领域，BNP尤其是NT-proBNP的检测应用较少。文章就NT-proBNP在心脑血管疾病，尤其是在缺血性脑血管病中的作用进行了综述。Brain natfiuretic peptide （BNP） is one of the most sensitive and specific laboratory indicators during cardiac dysfunction. N-Terminal pro-brain natriuretic peptide （NT-proBNP） is the N-terminal precursor of BNP. The functions of both are not consistent, but its physicochemical properties are superior to BNP. Now it has been widely used in the diagnosis and treatment monitoring of cardiovascular diseases. In the field of stroke, the testing and application of BNP, especially NT-proBNP is less. This article reviews the roles of NT-proBNP in cardio-cerebrovascular diseases, especially in ischemic cerebrovascular disease.

关 键 词：利钠肽 脑 肽碎片 卒中 脑缺血 心力衰竭 生物学标记 

分 类 号：R743[医药卫生—神经病学与精神病学]