有机锡致海洋腹足类性畸变分子机制的研究进展  

Research Progress on Molecular Mechanism of Organotin-Induced Imposex in Marine Gastropods

作　　者：肖丽萍[1] 王淑红[1] 邹志华[1] 王艺磊[1] 张子平 

机构地区：[1]集美大学水产学院,厦门361021 [2]西东大学生物系,美国新泽西州07079

出　　处：《生态毒理学报》2013年第3期315-323,306,共9页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金(20877034);福建省科技重点项目(2011N0022);国际科学基金(A/4717-1);集美大学创新团队基金(2010A001)

摘　　要：有机锡作为防污损生物附着添加剂曾被大量使用,在极低浓度下就能诱发腹足类发生性畸变现象,严重危害了海洋生态系统的平衡。虽然三丁基锡已被国际海事组织全球禁用,但目前报道的环境有机锡污染仍然非常严重,而且其致毒机制一直众说纷纭。首先,简述了腹足类性畸变及其在世界各个海域有机锡污染监测中的应用,重点综述了有机锡致海洋腹足类性畸变分子机制的3种假说:脊椎动物类型的类固醇激素假说、神经肽假说以及视黄酸X受体(retinoid X receptor,RXR)假说,另外,结合快速发展的分子生物学技术,探讨了研究腹足类性畸变分子机制的新思路和新方法。Organotin compounds had been widely used as additives of antifouling paints. These compounds were demonstrated as inducers of imposex in gastropods at very low concentrations, which severely damaged the marine ecosystems. Even though a global ban on tributyltin has been enacted by the International Mari-time Organization, the organotin pollution is still serious as reported recently, and the molecular mechanism of imposex caused by organotin compounds is in dispute. In this article, the imposex caused by the organotin in gastropods and its application for evaluating world wide organotin contamination were briefly reviewed. Three hypothesized molecular mechanisms for organotin-induced imposex in gastropods were highlighted as follows： imbalance of vertebrate-type sex steroids level, abnormal release of neuropeptide, and activation of retinoid X receptor. Additionally, new thoughts and methods adhere to the newly developed molecular technique were proposed to investigate the overall molecular mechanisms of imposex in gastropods.

关 键 词：有机锡 腹足类 性畸变 分子机制 

分 类 号：X171.5[环境科学与工程—环境科学]