三联疗法联合麦滋林-S颗粒对幽门螺杆菌阳性患者胃溃疡的疗效  

Efficacy of marzulene-S combined with triple therapy in treating Hp-positive patients with gastric ulcer

作　　者：戎建明[1] 陆恒[1] 许莲娥[1] 刘炯[1] 季洪赞[1] 汪芳裕[1] 

机构地区：[1]南京军区南京总医院消化病科,江苏省210002

出　　处：《江苏医药》2013年第11期1269-1270,共2页Jiangsu Medical Journal

摘　　要：目的观察三联疗法联合麦滋林-S颗粒治疗成人活动期胃溃疡的效果。方法 164例幽门螺杆菌(Hp)检测阳性并经胃镜证实的胃溃疡患者随机分为两组:对照组80例应用奥美拉唑20mg+阿莫西林1000mg+克拉霉素500mg,2次/d三联治疗7d后,继续单用奥美拉唑20mg,1次/d,连服8周;治疗组84例在对照组基础上加服麦滋林-S颗粒0.67g,3次/d,共9周。治疗前后行胃镜检查和Hp检测,记录治疗前后溃疡愈合、Hp感染及治疗后半年溃疡复发情况。结果治疗组临床显效率78.6%,高于对照组的56.3%(P<0.05)。治疗结束后6个月随访,治疗组复发率3.6%,低于对照组的12.5%(P<0.05)。结论三联疗法联合麦滋林-S颗粒对Hp阳性患者胃溃疡的疗效较好,并能减少复发率。Objective To explore the efficacy of marzulene-S combined with triple therapy （omeprazole 20 nag＋amoxyicillin 1.0 g＋clarithromycin 500 rag, bid for 7 days and followed by omeprazole 20 nag daily for 8 weeks） in treating Helicobacter pylori（Hp）-positive patients with active gastric ulcer. Methods A total of 164 Hp-positive cases with active gastric ulcer confirmed by gastroscopy was randomly treated with triple therapy plus marzulene-S 0. 67 g, tid for 9 weeks （group A,84 cases） or triple therapy（group B, 80 cases）. The therapeutic efficacy was evaluated by gastroscopy and examination for Hp before and after treatment. Results The excellence rate was higher in group A than that in group B （78. 6% vs. 56. 3%） （P〈0. 05）. The recurrence rate was lower in group A than that in group B （3.6% vs. 12.5%. ） （P〈0. 05）. Conclusion Marzulene-S combined with triple therapy is reliable and effective in treating gastric ulcer patients with Hp-positive patients with active gastric ulcer with less recurrence rate.

关 键 词：麦滋林-S颗粒 幽门螺杆菌 胃溃疡 

分 类 号：R574[医药卫生—消化系统]