贵州地区原发性肝癌危险因素1:2配对病例对照研究  

The risk factors for primary hepatic carcinoma in Guizhou province:an 1:2 matched case-controlled study

作　　者：谭家武[1] 张权[1] 程明亮[1] 赵雪珂[1] 王文志[1] 陈莎莎[1] 

机构地区：[1]贵阳医学院附属医院感染病科,贵州省550004

出　　处：《江苏医药》2013年第11期1274-1276,共3页Jiangsu Medical Journal

基　　金：国家重点基础研究发展计划项目子课题(2011CB512114)

摘　　要：目的探讨贵州地区原发性肝癌(肝癌)的危险因素。方法以贵州各地多家综合性大医院2011年6月-2012年4月确诊的150例新发肝癌患者为研究对象,按照同性别、年龄、居住地进行1∶2配对,采用问卷调查进行病例对照研究。结果经多因素条件Logistic回归分析显示,5年前经济不良(OR=2.967,95%CI:1.218-7.227)、肝癌家族史(OR=5.364,95%CI=1.437-20.021)、饮酒(OR=4.519,95%CI=1.926-10.603)、HBsAg阳性(OR=7.298,95%CI=3.167-16.817)、HBV DNA≥1×103IU/ml(OR=9.136,95%CI=3.962-21.063)均与肝癌发病密切相关。结论 5年前经济不良、肝癌家族史、饮酒、HBsAg阳性、HBV DNA≥1×103IU/ml是贵州地区肝癌的危险因素。Objective To study the risk factors for primary hepatic carcinoma （PHC） in Guizhou province. Methods An 1：2 matched case-controlled study was carried out in 150 cases with new PHC from June 2011 to April 2012 in several General Hospitals in Guizhou province, which were matched with gender, age and residence. Both of PHC cases and controls were investigated by questionnaires. Results The multivariate conditional logistic regression analysis showed that the risk factors for PHC included poor economic situation during the past five years（OR=2. 967, 95%CI= 1. 218-7. 227）,the family history of PHC（OR=5. 364,95%CI： 1. 437-20. 021）, preferring intake of alcohol（OR=4. 519, 95% CI = 1. 926-10. 603 ）, HBsAg-positive （OR=7. 298, 95% CI ： 3. 167- 16. 817） ,and HBV DNA≥1×10^3IU/ml（OR：9. 136,95%CI=3. 962-21. 063）. Conclusion The risk factors for PHC in Guizhou province are poor economic status during the past five years, family history of PHC, drinking, HBsAg-positive and HBV DNA≥1 × 10^3 IU/ml.

关 键 词：原发性肝癌 

分 类 号：R735[医药卫生—肿瘤]