超分割放疗治疗副鼻窦癌的毒副反应和近期疗效观察  

Evaluation of the preliminary results and toxicity of hyperfractionated radiotherapy for malignancies of the paranasal sinuses

作　　者：白雪[1] 刘美莲[1] 黄辉[1] 蔡锐[1] 邹良群[1] 冯凯华[1] 

机构地区：[1]桂林医学院附属医院放疗科,广西桂林541001

出　　处：《华夏医学》2013年第2期289-292,共4页Acta Medicinae Sinica

基　　金：广西壮族自治区卫生厅资助课题(Z2008283)

摘　　要：目的:探讨超分割放射治疗副鼻窦癌的毒副反应及近期疗效。方法:回顾性分析26例接受术后超分割放射治疗的副鼻窦癌患者,与常规分割放疗组患者对照,比较两组近期疗效及毒副反应的差异。结果:超分割治疗组3年局控率明显提高,急性期黏膜反应较重,晚期眼部毒副反应较轻,两组间差异有统计学意义(P<0.05),而3年总生存率两组间差异无统计学意义。结论:超分割放疗能够改善局部控制率,且明显降低放射性视网膜病的发病率,可改善患者的生活质量。Objective：To evaluate the preliminary results and toxicity of postoperative hyperfraction- ated radiotherapy for malignancies of the paranasal sinuses. Methods. Clinical data of paranasal malignancy patients, treated by hyperfractionated radiotherapy, were reviewed. These patients were then compared with a cohort of paranasal malignancy patients treated by conventional fractionation radiotherapy. The preliminary outcomes and radiation-related sequelae of the two groups were compared. Results： Compared with the conventional fractionation radiotherapy, hyperfractionated radiotherapy significantly improved the 3-year locoregional control rate （P〈0.05）. There was no significant differences in the 3-year overall survival rate between the two groups. The occurrence rates of mucositis were significantly higher in hyperfractionated radiotherapy group. Hyperfractionation was associated with a significantly lower incidence of radiation retinopathy. Conclusion：Hyperfractionated radiotherapy can significantly improves the locoregional control and reduce the incidence rate of radiation retinopathy, improve the quality of life.

关 键 词：副鼻窦癌 超分割 放射治疗 毒副反应 

分 类 号：R739.62[医药卫生—肿瘤]