磁刺激穴位复杂脑功能网络构建与分析  

Construction and analysis of complex brain functional network under acupoint magnetic stimulation

作　　者：尹宁[1] 徐桂芝[1] 周茜[1] 

机构地区：[1]河北工业大学 电磁场与电器可靠性省部共建重点实验室,天津300130

出　　处：《物理学报》2013年第11期559-566,共8页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:50877023);高等学校博士学科点专项科研基金(批准号:20121317110002);河北省自然科学基金(批准号:F2012202016)资助的课题~~

摘　　要：本文采用互信息方法对磁刺激内关穴过程中的脑电信号进行了两两通道间非线性时域关联特性分析,构建了不同频率刺激前、刺激中、刺激后的脑功能网络,并基于复杂网络理论对脑功能网络的特征进行了深入研究.结果表明,磁刺激频率为3Hz时,大脑功能网络的平均度、平均聚类系数和全局效率与刺激前相比均有显著升高,平均路径长度显著降低,并且相应脑功能网络的"小世界"属性有所增强,信息在大脑各区域间的传递更加高效.本研究首次开展了磁刺激穴位复杂脑功能网络的构建与分析,为探索磁刺激穴位对大脑神经调节的作用和机理提供新思路和新方法.Brain is a complex nonlinear dynamic system consisting of related functional regions that can be described by the complex network model. Acupoint magnetic stimulation is an equivalent external stimulus for brain, which can be used as an important technical method to study the regulation mechanism of complex nervous system. It is of great significance to research the effect of acupoint magnetic stimulation on the structure and characteristics of brain functional network. Magnetic stimulation was applied to Neiguan （PC6） and the acquired EEG data were analyzed using dual-channel nonlinear method of mutual information in time domain. The corresponding brain functional networks before, during and after a magnetic stimulation were constructed and the characteristic parameters were studied based on the complex network theory. Results show that the average degree, average clustering coefficient and global efficiency of the brain functional network were increased under magnetic stimulation frequency of 3 Hz, while the average path length was reduced. The small world attribution of the corresponding functional network was enhanced, which made the information transfer among brain regions more efficiently. The brain functional networks under acupoint magnetic stimulation is studied for the first time as far as we know, which provides a new idea and approach to investigate the effect and regulation mechanism of transcutaneous acupoint magnetic stimulation to the complex nervous system.

关 键 词：复杂网络 磁刺激 脑功能网络 互信息 

分 类 号：O157.5[理学—数学]