肝硬化对肠道屏障功能损害的研究  

Liver Cirrhosis Causes Intestinal Mucosa Barrier Failure

作　　者：熊智强[1] 刘丽 

机构地区：[1]南华大学长沙市第一医院,湖南长沙410005 [2]长沙市第一医院消化内科,湖南长沙410005

出　　处：《现代生物医学进展》2013年第15期2979-2982,共4页Progress in Modern Biomedicine

基　　金：湖南省自然科学基金项目(12JJ3105)

摘　　要：肝硬化是一种由多病因造成的慢性疾病。随着肠道屏障功能障碍日益受到重视,针对肝硬化患者肠道屏障功能变化的研究及临床干预越来越受到学者关注。肝硬化可造成患者肠道屏障损害,使肠道细菌和内毒素进人机体,引起内毒素血症及自发性腹膜炎,进一步加重患者肝硬化病情,形成恶性循环。此文就肝硬化对肠道屏障的损害机制、检测方法和干预措施进展作一综述。Liver cirrhosis is a chronic disease.Ever-increasing attention has been paid to intestinal mucosal barrier dysfunction.The research on changes in intestinal mucosal barrier function in patients with liver cirrhosis diseases has attracted wide attention.Intestinal mucosa barrier failure caused by liver cirrhosis can permeate intestinal bacteria and endotoxin into blood and abdominal cavity,thus lead to endotoxemia and spontaneous bacterial peritonitis,which can cause a vicious cycle.This review will provide a progress on the pathogenesis,testing and therapeutic measures of intestinal mucosal barrier failure caused by liver cirrhosis.

关 键 词：肝硬化 门静脉高压 肠道屏障功能 

分 类 号：R575.2[医药卫生—消化系统]