氯化钾对治疗重症肌无力疗效的影响  

Effects of Therapeutic Efficacy of Potassium Chloride for Myasthenia Gravis

作　　者：钟小劲 何锦照 陈娟婷[2] 

机构地区：[1]河源市人民医院神经内科,广东河源517000 [2]江门市中心医院院感科,广东江门529000

出　　处：《医学综述》2013年第12期2279-2280,共2页Medical Recapitulate

摘　　要：目的观察氯化钾对治疗重症肌无力(MG)疗效的影响。方法将2005年1月至2010年12月到河源市人民医院就诊的54例MG患者随机分为两组:对照组(29例)采用单纯嗅吡斯的明和泼尼松片治疗,治疗组(25例)在对照组治疗的基础上加服氯化钾治疗,分别于治疗后2、6、12周进行疗效观察。结果两组患者在治疗后2、6周的临床疗效比较差异均有统计学意义(P<0.05),治疗后12周治疗组的临床症状缓解快,复发率低,且临床症状疗效控制好。结论使用氯化钾联合治疗MG有助于改善患者的复发率及临床症状。Objective To investigate the effects of potassium chloride on therapeutic efficacy for myas-thenia gravis（MG）. Methods Fifty-four MG patients,received by People＇s Hospital of Heyuan in the peri-od from January 2005 to December 2010, were randomly divided into two groups. 29 patients as a control group were treated with pyridostigmine bromide and prednisone while 25 patients as a treatment group were treated with pyridostigmine bromide, prednisone and potassium chloride. Patients of these two groups were investigated on effects of therapeutic efficacy after 2 weeks, 6 weeks and 12 weeks respectively. Results Statistical significance of clinical efficacy（ P 〈 0.05 ）had been obtained between the treatment group and the control group after 2 weeks and 6 weeks, respectively. Clinical symptoms of patients in the treatment group was alleviated more quickly and better controlled comparing with that in the control group. Patients in the treatment group had a lower recurrence rate. Conclusion The lower recurrent rate and better clinical symp-tom remission of MG patients were obtained when treated by combination with potassium chloride.

关 键 词：重症肌无力 氯化钾 临床疗效 

分 类 号：R746.1[医药卫生—神经病学与精神病学]