国产奥美拉唑治疗急性非静脉曲张性上消化道出血的Meta分析  

Effectiveness and Safety of China-Made Omeprazole in Treating Acute Non-Variceal Upper Gastrointestinal Bleeding: A Meta-Analysis

作　　者：刘文平[1] 黄彩云[1] 

机构地区：[1]福建医科大学附属漳州市医院消化内科,福建漳州363000

出　　处：《中国循证医学杂志》2013年第6期723-727,共5页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价国产奥美拉唑治疗急性非静脉曲张性上消化道出血的疗效和安全性。方法计算机检索PubMed、MEDLINE、Springer、e Cochrane Library、CNKI、VIP、CBM、WanFang Data等数据库,收集国产奥美拉唑治疗急性非静脉曲张性上消化道出血的随机对照试验(RCT),检索时限均为建库至2012年12月,并追溯纳入研究的参考文献。由两位研究者按照纳入与排除标准独立筛选文献、提取资料和评价质量后,采用RevMan 5.1软件进行Meta分析。结果纳入11个RCT,共1 075例患者(试验组544例,对照组531例)。Meta分析结果显示,国产奥美拉唑与进口奥美拉唑相比,在急性非静脉曲张性上消化道出血的总有效率[OR=0.68,95%CI(0.35,1.33),P=0.26]和不良反应发生率[RR=1.33,95%CI(0.45,3.91),P=0.60]方面,两组差异无统计学意义。结论国产奥美拉唑治疗急性非静脉曲张性上消化道出血疗效与进口奥美拉相当,安全有效。Objective To systematically evaluate the effectiveness and safety of China-made omeprazole in treat- ing acute non-variceal upper gastrointestinal bleeding. Methods Such databases as PubMed, MEDLINE, Springer, The Cochrane Library, CNKI, VIP, CBM and WanFang data were searched to collect the randomized controlled trials （RCTs） about China-made omeprazole in treating acute non-variceal upper gastrointestinal bleeding, and the references of in- cluded studies were also retrieved. The retrieval time was from inception to December 2012. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and assessed the quality, and then the meta-analysis was conducted by using RevMan 5.1 software. Results A total of 11 RCTs were included. Among all 1 075 patients, 544 were in the treatment group, while the other 531 were in the control group. The results of meta- analysis showed that, there were no significant differences in the total effective rate （OR=0.68, 95%CI 0.35 to 1.33, P=0.26） and safety （RR=l.33, 95%CI 0.45 to 3.91, P=0.96） between the China-made omeprazole and imported omeprazole. Con- clusion China-made omeprazole is effective and safe in treating acute non-variceal upper gastrointestinal bleeding in comparison with the imported omeprazole.

关 键 词：国产奥美拉唑 进口奥美拉唑 非静脉曲张性上消化道出血 疗效 安全性 META分析 系统评价 随机对照试验 

分 类 号：R573.2[医药卫生—消化系统]