基底节区脑出血患者血清VEGF和CRP水平及其临床意义  

Clinical Significance and Levels of Serum VEGF and CRP in the Patients with Cerebral Hemorrhage of the Basal Ganglia Territory

作　　者：刘慧[1] 谢明[1] 

机构地区：[1]南华大学附属第一医院神经内科,湖南衡阳421001

出　　处：《中南医学科学杂志》2013年第3期297-300,共4页Medical Science Journal of Central South China

摘　　要：目的探讨血管内皮生长因子和C反应蛋白在急性基底节区脑出血患者中的动态变化及其临床意义。方法在85例急性基底节区脑出血患者和75例健康对照者中,采用双抗体夹心酶联免疫吸附技术测定脑出血发生24 h、3天、7天、14天时血清VEGF的水平,用散射比浊法测定脑出血发生24 h内血清CRP水平,并分析它们与病情程度及出血部位的关系。结果急性脑出血组血清VEGF和CRP水平均明显高于健康对照组(P<0.05)。脑出血发生后24 h内血清VEGF水平开始升高,在7天时达到高峰,14天时仍维持较高水平。血清VEGF水平与病情严重程度密切相关,但与出血部位不相关。CRP异常率为68.24%(58/85),随病情呈程度轻、中、重度的增加,血清CRP水平及异常率也逐渐增加。结论急性基底节区脑出血患者血清VEGF及CRP水平与病情严重程度相关,但与出血部位并不相关。Objective To explore the levels of Vascular endothelial growth factor and C-reactive protein in the patients with acute cerebral hemorrhage of the basal ganglia territory,and study their clinical significance during different phases.Method The serum VEGF levels were determined at 24h,3d,7d and 14d after the onset of disease by enzyme linked immunesorbent assay and the serum CRP levels were measured by scatter turbidimetry within 24h after onset of disease in all subjects.The relationships between serum VEGF or CRP and the pathogenetic condition or bleeding site were analyzed.Results The levels of VEGF and CRP in the patients with acute cerebral hemorrhage of the basal ganglia territory were much higher than those in control group（P0.05）.The levels of serum VEGF gradually increased after the onset of acute cerebral hemorrhage and reached the peak at 7 d,and did not return to normal level at 14 d,and it was related to the severity of the disease but not to bleeding site.The abnormal rate of case group was 68.24%,and along with the increase of severity of disease situation from light to moderate till severe,the CRP levels and its abnormal rate were elevated（mild level： 48.15%（16.77±1.57）,moderate level： 65.52%（33.73±3.44）,severe level： 89.66%（41.42±5.62）.Conclusions The serum VEGF and CRP levels might be related to the volume of hemorrhage but not to bleeding site.

关 键 词：急性脑出血 血管内皮生长因子 C反应蛋白 出血部位 

分 类 号：R743.34[医药卫生—神经病学与精神病学]