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机构地区:[1]河南省精神病医院精神科,河南新乡453002
出 处:《中国民康医学》2013年第11期11-14,共4页Medical Journal of Chinese People’s Health
基 金:河南省医学科技攻关计划(200803078)
摘 要:目的:比较利培酮片合用舒肝解郁胶囊与单用利培酮片对Ⅱ型精神分裂症患者精神症状、认知功能的疗效及差异。方法:将82例患者随机分为合用组(40例,利培酮片合并舒肝解郁胶囊治疗)和单用组(42例,单用利培酮片治疗),并于入组时、入组8周进行阳性与阴性症状评定量表(Positive and Negative syndrome Scale for schizophrenia,PANSS)、不良反应量表(Treatment Emergent Symptoms scale,TESS)、事件相关电位(Event-Related Potentials,ERP)和探究性眼动分析(Exploratory Eye Movement,EEM)的评定,与对照组(40例,不服用任何药物)进行比较及患者组间比较。结果:合用组与单用组入组8周PANSS量表各项分均较入组前降低(P<0.05)。与入组时相比,入组8周时,合用组N2、P3潜伏期缩短,P3波幅、NEF增高,单用组P3潜伏期缩短,差异有统计学意义(P<0.05);合用组N2、P3潜伏期短于单用组,P3波幅、NEF高于单用组,差异有统计学意义(P<0.05)。结论:舒肝解郁胶囊能显著改善Ⅱ型精神分裂症患者的认知功能。Objective :To compare curative effects and differences of risperidone tablets combined with shugan -jieyu capsules and single risperidone tablets on symptoms and cognitive function for type II schizophrenia patients. Methods:82 schizophrenics were divided into combination group ( n = 40, administered by risperidone tablets combination with shugan - jieyu capsules) and single group (n = 42, administered by risperidane tablets). Positive and negative syndrome scale for schizophrenia (PANSS), treatment e- mergent symptoms scale (TESS), exploratory eye movement (EEM), and event- related potentials (ERP) were assessed before and 8 weeks after the treatment, which were compared between patient group and control group ( n = 40, treated without drugs), and among the patient groups. Results: The score of each item in PANSS of combination group and single group was reduced 8 weeks after the treatment compared with that before the treatment ( P 〈 0.05 ). Compared with those before the treatment, the N2 and P300 latent peri- ods 8 weeks after the treatment in combination group were shortened, however, the 1)300 amplitude and number of NEF increased; the P300 latent period in single group were shortened, and the differences were statistically significant (P 〈 0.05 ). The N2 and P300 la- tent periods of single group 8 weeks after the treatment were significantly longer than those of combination group, whereas the P300 am- plitude and number of NEF were lower than those of combination group, and the differences were statistically significant (P 〈 0.05). Conclusions: Shugan- jieyu capsules can improve cognitive function for type II schizophrenics.
分 类 号:R749.3[医药卫生—神经病学与精神病学]
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