早期老年痴呆患者血p-tau、Aβ1-42与尿AD7c-NTP含量比较研究  

Study of Plasma Levels of p-tau,Aβ1-42 and Urine Level of AD7c-NTP in Alzheimer′s Disease and Vascular Dementia in Early Stage

作　　者：官颖[1] 官捷[2] 

机构地区：[1]辽宁中医药大学附属医院干诊病房,辽宁沈阳110032 [2]沈阳军区政治部门诊部,辽宁沈阳110013

出　　处：《辽宁中医杂志》2013年第6期1173-1175,共3页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:研究早期阿尔兹海默病(AD)和血管性痴呆(VD)患者血p-tau、Aβ1-42和尿AD7c-NTP含量的变化,为诊断早期AD、VD提供理论依据。方法:采用酶联免疫吸附法(ELISA),检测AD组25例,VD组25例,对照组20例血中p-tau;Aβ1-42含量及尿中AD7c-NTP含量。结果:早期AD组血p-tau、Aβ1-42蛋白含量和尿中AD7c-NTP含量明显高于VD组和对照组,具有显著性差异(P<0.05),而VD组与对照组比较没有显著性差异(P>0.05)。结论:联合检测血p-tau、Aβ1-42含量和尿AD7c-NTP含量可提高早期AD与VD的诊断与鉴别诊断。Objective ：To study the early diagnostic significance for detecting the plasma levels of ptau ,Aβ1 -42 and urine level of AD7c - NTP in Alzheimer＇s disease and vascular dementia. Methods：The plasma levels of p - tau, Aβ1 -42 and urine level of AD7c - NTP were determined using enzyme - linked immunosorbent assay in 70 elderly people, who were divided into three groups：the AD group（ n = 25 ）,the VD group（ n = 25 ） and the normal control group （n = 20）. Results：The plasma levels of ptau, Aβ1 -42 and urine level of ADTc - NTP for AD group were higher than that of VD group and control group （ P 〈 0. 05 ） , while there was no significant difference between VD group and control group （P 〉 0. 05 ）. Conclusion：The associating method for determining plasma levels of p - tau, Aβ1 -42 and urine level of AD7c - NTP might enhance the diagnosis and differential diagnosis of AD and VD in early stage.

关 键 词：阿尔兹海默病(AD) 血管性痴呆(VD) p-tau AΒ1-42 AD7c-NTP 

分 类 号：R749.16[医药卫生—神经病学与精神病学]