地被菊提取液对人胃癌SGC-7901细胞的影响  

Effect of the Extracts from Dendranthema Grandiflorum on the SGC-7901 Gastric Cancer Cells of Human

作　　者：沈延春[1] 黄蓉[1] 庹新兰[1] 

机构地区：[1]江汉大学医学院医学系,湖北省武汉市430056

出　　处：《医学理论与实践》2013年第12期1570-1571,共2页The Journal of Medical Theory and Practice

摘　　要：目的:研究地被菊提取液中的各种成分对人胃癌SGC-7901细胞的影响,探讨其对人胃癌SGC-7901细胞抑制效果最好浓度梯度范围。方法:运用煎煮法制备地被菊提取液和细胞培养技术培养人胃癌SGC-7901细胞,MTT比色法和流式细胞术法检测人胃癌SGC-7901细胞的生长状况。结果:地被菊提取液促进人胃癌SGC-7901细胞的凋亡,浓度梯度为100～10 000μg/ml时诱导凋亡作用明显(P<0.05);地被菊提取液浓度在500～2 000μg/ml范围内能显著性地抑制人胃癌SGC-7901细胞生长繁殖(P<0.05)。结论:地被菊提取液能够促进细胞的凋亡,在500～2 000μg/ml内能抑制人胃癌SGC-7901细胞的生长繁殖,具剂量-效应关系。To investigate the concentration gradient effects of the extracts form Dendranthema grandiflorum on the gastric cancer. Methods： Use decoction method to lixiviate the powder of Dendranthema grandiflorum and cell culture technology to train the SGC-7901 gastric cancer cells of human. After, using the MTT method and flow cytometric art to measure the changes of SGC-7901 gastric cancer cell of human growth. And seek the best concentration gradient range to inhibite the SGC-7901 gastric cancer cells of human growth. Results： The extracts form Dendranthema grandiflorum can promote the SGC-7901 gastric cancer of human cells apoptosis, specially in range of 500~2 000/μg/ml has statistically significant difference （P〈0. 05）. It can inhibite the SGC-7901 gastric cancer cells of huamn growth in range of 500~2 000/μg/ml and has statistically significant difference （P〈0. 05）. Conclusion. The extracts form Dendranthema grandiflorum can inhibit the SGC-7901 gastric cancer cells of huamn growth in certain concentration gradient range, and has certain doses-effect relations

关 键 词：胃癌 SGC-7901 地被菊 

分 类 号：R735.2[医药卫生—肿瘤]