抑郁症患者头颅磁共振的研究  

Brain MRI investigation of patients with depression

作　　者：卢妍妍[1] 阎琳[1] 陈岩[2] 蒋珊[1] 李幼辉[1] 

机构地区：[1]郑州大学第一附属医院精神科,450052 [2]河南省医学会

出　　处：《中国实用医刊》2013年第12期45-47,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨抑郁症患者脑结构形态学的表现。方法利用头颅磁共振技术分析126例抑郁症患者脑结构的表现，并对重度与轻中度抑郁症的脑区结构改变进行对比研究。结果126例抑郁症患者的头颅磁共振结果中异常53例，占42．06％。56例重度抑郁症患者头颅磁共振结果中异常27例，占48．21％。重度抑郁症组较轻中度抑郁症组存在额叶（具体为左侧额叶）脱髓鞘改变，差异有统计学意义（P〈0．05），其他脑区脑结构改变差异无统计学意义（P〉0．05）。结论抑郁症患者脑结构存在异常改变的比例较高。左侧额叶脑区的结构改变可能与抑郁症的严重程度相关。Objective To investigate the manifestation of brain structural morphology of patients with depression. Methods A study using MRI was made on brain structure of 126 patients with depression, and a comparative study was made on the structural abnormalities of cerebral regions between severe depression group and mild-to-moderate depression group. Results In 126 MRI findings of patients with depression, 53 cases were abnormal （ which accounted for 42.06% ）. In 56 MRI findings of patients with major depression, 27 cases were abnormal （which accounted for 48.21% ）. There was significant difference in the frontal lobe （specially, the left frontal lobe） demyelination between major depression group and mild-to-moderate depression group （P 〈 0.05 ）, while no difference in structural abnormalities of other cerebral regions （P 〉 0.05 ）. Conclusions Rate of structural abnormalities of brain in patients with depression is high. Structural abnormalities of the left frontal lobe region may be related to the severity of depression.

关 键 词：抑郁症 汉密尔顿抑郁量表 磁共振 重度抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]