魔芋葡甘聚糖海绵状创面敷料的制备与表征  

Preparation and Characterization of Konjac Glucomannan Sponge Wound Dressing

作　　者：张传杰[1,2] 熊伟[1] 王恒洲[1] 刘云[1] 朱平[1,2] 

机构地区：[1]武汉纺织大学化学与化工学院,湖北武汉430073 [2]武汉纺织大学新型纺织材料绿色加工及其功能化教育部重点实验室,湖北武汉430073

出　　处：《高分子材料科学与工程》2013年第6期145-148,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(51073122);湖北省自然科学基金资助项目(2009CDA033);武汉纺织大学校基金(2011)

摘　　要：以质量分数为1.0%的魔芋葡甘聚糖水溶液为原料,质量分数为3.0%的氢氧化钠乙醇溶液为凝固浴,采用冷冻诱导相分离的方法制备了能够大量吸收水分而不溶解的海绵材料。研究结果表明,该海绵的表面和内部具有均匀、连通的孔隙结构,孔径大小为400μm左右,孔隙率为93.87%,透气率为45.30%,对人造血浆的吸液量和保液量分别为25.98g/g和3.36 g/g,海绵的厚度为3 mm,表观密度为25.15 mg/cm3,拉伸强度为0.43 MPa。各项性能均优于或接近市售的海藻酸钙和粘胶非织造布创面敷料的水平,可用于治疗手术伤口、烧烫伤创面等各种类型的皮肤创伤。Konjac glucomannan （KGM） sponge, which can absorb much water without being dissolved, was prepared by vacuum freeze-drying process with 1.0 96 KGM aqueous solution as raw material and 3.0 % sodium hydroxide ethylalcohol solution as coagulating bath. The structure of KGM sponge was characterized by FT-IR and SEM, and its handle and visual determination, physical properties, mechanical properties, porosity, permeating rate, absorbing and preserving liquid capacity were measured. There are uniform and connected porosity structures at surface and inside of KGM sponge and the diameter of these pores is about 400μm. The porosity and air penetrability of KGM sponge are 93.87 % and 45.30 % respectively, while its absorbing and preserving liquid capacity to man- made plasma are 25.98 g/g and 3.36 g/g respectively. The thickness, apparent density and tensile strength of KGM sponge are 3 mm, 25.15 mg/cm^3 and 0.43 MPa respectively. In short, the performances of KGM sponge are better than or close to those of calcium alginate and viscose non-woven wound dressing which are commercially available, so KGM sponge can be used in the treatment of skin wound such as surgical wound or scald wound.

关 键 词：魔芋葡甘聚糖 海绵 创面敷料 冷冻干燥 力学性能 

分 类 号：O636.1[理学—高分子化学]