自噬在宫颈癌发生发展及治疗中的作用  

Role of Autophagy in the Initiation,Progression and Treatment of Cervical Cancer

作　　者：张碧蓉[1] 谢丽玲[2] 

机构地区：[1]湖南省长沙市妇幼保健院妇科,湖南长沙410007 [2]广西右江民族医学院附属医院妇产科

出　　处：《实用预防医学》2013年第6期768-768,F0003,共2页Practical Preventive Medicine

摘　　要：宫颈癌是威胁全球女性健康的恶性肿瘤。尽管人乳头状瘤病毒的感染被认为是导致宫颈癌的主要因素,但仅病毒感染并不足以解释其发生发展。宫颈癌的发病机制包括癌基因激活、抑癌基因失活和免疫调节失衡在内的一系列病理改变,探索宫颈癌的发病机制对于其预防和治疗至关重要。自噬是维持细胞代谢稳态的重要免疫学机制,肿瘤发生发展与自噬密切相关。本文就自噬在宫颈癌发生发展中的作用展开阐述,并探讨以自噬为靶点的潜在宫颈癌治疗策略。Cervical cancer is a malignant tumor that poses a threat to women＇s health worldwide.Although the human papillomavirus infection is considered the major causative agent of cervical cancer,the viral infection alone is not sufficient for cancer initiation.The pathogenesis of cervical cancer is indeed complex;therefore the exploration of the complex cellular/molecular mechanisms underlying the initiation and progression of the cervical cancer is essential for prevention and treatment of cervical cancer.Autophagy plays an important role in maintaining cellular homeostasis,and it is closely associated with tumor initiation and progression.This article reviews the role of autophagy in cervical cancer,and the therapy about cervical cancer related to autophagy is discussed as well.

关 键 词：宫颈癌 自噬 增殖 治疗 

分 类 号：R737.33[医药卫生—肿瘤]