肌萎缩侧索硬化症26例临床诊治分析  

Clinical Analysis of 26 Patients with Amyotrophic Lateral Sclerosis

作　　者：庞卫锋[1] 沈朝阳[1] 方琪[2] 

机构地区：[1]常州市第七人民医院神经内科,江苏常州213011 [2]苏州大学附属第一医院神经内科,江苏苏州215006

出　　处：《临床误诊误治》2013年第6期52-54,共3页Clinical Misdiagnosis & Mistherapy

摘　　要：目的探讨肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)的临床特征,为进一步研究病因、发病机制和治疗提供临床数据支持。方法回顾性分析26例ALS的临床特点、症状、体征、既往史及实验室检查资料。结果本组男17例,女9例;发病年龄(47.7±8.9)岁,发病年龄高峰39～51岁,30岁以前发病4例,70岁以后发病1例。隐袭起病23例,亚急性起病3例,病情均进展缓慢,首发症状以肌无力为主,均经神经电生理检查及肌电图检查明确诊断。均予糖皮质激素、能量合剂等治疗,其中1例死亡,余25例症状均有不同程度好转。结论 ALS是一种与年龄相关、好发于男性的疾病,疾病进展遵循一定规律。神经电生理检查及肌电图对ALS的确诊和鉴别诊断有重要价值,早期治疗可改善预后。Objective To explore clinical features of amyotrophic lateral sclerosis （ALS） so as to provide clinical data for the further research in etiological factors, pathogenesis and therapy. Methods Clinical characteristics, symptoms, signs, past medical history and data of lahoratory examinations of 26 patients with ALS were retrospectively analyzed. Results The study included 17 males and 9 females; age of onset was （47.7±8.9） years, and peak age of onset was 39 - 51 years. Pathogenesy occurred before the age of 30 in 4 patients and after the age of 70 in 1 patient. Onste of 23 patients did not show clinical symptoms, and 3 patients were subacute type. Main initial symptom of ALS was muscle weakness with slowing progression, and ALS was confirmed by nerve electrophysiologic study and electromyography. Glucocorticoids and energy mixtures were given, and then 25 patients improved to a certain degree but 1 patient died. Conclusion ALS is an age-related and male predominant disease. The development of ALS has its characteristics. Nerve clectrophysiologic study and electromyography have important values in diagnosis and differential diagnosis of ALS. Early treatment may result in better prognosis.

关 键 词：肌萎缩侧索硬化 神经电生理检查 肌电图 

分 类 号：R744[医药卫生—神经病学与精神病学]