化疗并用云芝糖肽对卵巢和子宫体癌患者免疫功能和生活质量的影响  

The Effect of PSP on Immune Function and Living Quality in Patients Receiving Chemotherapy for Gynecological Malignancies

作　　者：严伟[1] 祝亚平[1] 孙廷慰[1] 

机构地区：[1]上海市第一人民医院妇产科,上海200080

出　　处：《上海师范大学学报（自然科学版）》2000年第2期75-78,共4页Journal of Shanghai Normal University(Natural Sciences)

摘　　要：对 40例手术确诊的卵巢和子宫体癌患者 ,按期别及年龄配对分成 2组 ,各 2 0例 .A组(试验组 )接受化疗加云芝糖肽 .B组 (对照组 )单纯化疗 .观察两组治疗前后血免疫指标及生活质量指数的变化 .结果治疗前后 Karnofsky评分值 A组分别为 84± 9.6分及 90± 8.6分( P <0 .0 5) ,B组分别为 83± 9.2分及 80± 1 2 .8分 ( P >0 .0 5) ,治疗后 A组比 B组高 1 0分( P <0 .0 5) ;治疗后 A组和 B组的 CD+ 4 分别为 2 8.1 4± 4.1 0及 2 3.1 2± 3.97( P <0 .0 5) ;CD+ 4 /CD+ 8为 0 .96± 0 .1 7及 0 .75± 0 .2 1 ( P <0 .0 1 ) ;NK为 2 3.80± 4.90及 1 5.32± 3.90( P <0 .0 1 ) ,A组均明显高于 B组 .The effect of PSP on imm une function and living quality in patients receiving chemotherapy for gynecolog ical malignancies was studied 40 patients who had been operated on for gynecolog ical malignancies were divided into two groups equally in number accor ding to stage and age. In group the patients took PSP for two months on the dosa ge of 1.2g three times a day during a chemotherapy(PAC or MEP). In group B the p atients were treated the same schema of chemotherapy, but no PSP was used. The results show that the average KPS before and after the test were 84 and 90 in turn in group A (P<0.05), 83 and 80 in group B (P>0.05 ). The average KPS was 10 c redits higher in group A than that in group B after test (P<0.05). After the test, the concratration of T cell sub-groups, CD-+ 4, CD-+ 4/CD-+ 8 and NK cells increased in the blood obviously in group A, while in group B t hese indexes decreased slightly. The differences were significant statistically (P <0.05 for CD-+ 4, P<0.01 for CD-+ 4/CD-+ 8, <0.01 for NK cell).

关 键 词：云芝糖肽 卵巢癌 细胞免疫 生活质量 

分 类 号：R737.31[医药卫生—肿瘤] R730.3[医药卫生—临床医学]