非编码RNA与乳腺癌的研究进展  

Non-coding RNA and Breast Cancer

作　　者：卢山[1] 龚朝辉[1] 王琳[1] 徐进[1] 季林丹[1] 

机构地区：[1]宁波大学医学院,宁波315211

出　　处：《中国细胞生物学学报》2013年第6期889-896,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:30901216);浙江省教育厅科研基金(批准号:Y201224146);宁波市科技创新团队(批准号:2011B82014)资助的课题~~

摘　　要：乳腺癌是女性中最常见的和死亡率最高的肿瘤,生殖因素、激素水平、药物滥用和酗酒等构成了乳腺癌的危险因素。最近,大量研究发现,非编码RNA表达水平的改变与乳腺癌的发生、发展、诊断、治疗和预后密切相关。该文就非编码RNA与乳腺癌的关系及相关机理进行综述,有助于读者了解非编码RNA在乳腺癌发病过程中的重要性,为乳腺癌的综合防治提供线索。Breast cancer is one of the most common cancers and causes the highest mortality in women. Reproduction, hormone level, drug and alcohol abuse are the main risk factors for breast cancer. A large number of recent studies find that the expression level of non-coding RNA are associated with the development, diagnosis, treatment and prognosis of breast cancer. To help the readers understand the importance of non-coding RNA in the pathology of breast cancer, this review summarize current state of knowledge about the association between noncoding RNA and breast cancer, and the underlying mechanisms.

关 键 词：非编码RNA 乳腺癌 MIRNA 

分 类 号：R737.9[医药卫生—肿瘤]