盐酸帕洛司琼联合GDP方案治疗老年复发性非霍奇金淋巴瘤的临床研究  

Clinical Study on Palonosetron Combined with GDP Regimen in Treatment of Elderly Patients with Relapsed Non-Hodgkin's Lymphoma

作　　者：杭海芳[1] 朱琦[1] 唐勇[1] 邹丽芳[1] 姚一芸[1] 汪蕾[1] 程毅敏[1] 叶为德[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院血液内科,上海200011

出　　处：《肿瘤防治研究》2013年第6期531-533,共3页Cancer Research on Prevention and Treatment

基　　金：上海市卫生局科研课题面上项目资助课题(2010101)

摘　　要：目的评价盐酸帕洛司琼联合GDP(Palonosetron-GDP)方案治疗老年复发性非霍奇金淋巴瘤的临床疗效和不良反应。方法采用Palonosetron-GDP方案治疗28例老年复发性非霍奇金淋巴瘤患者,对接受3个疗程以上患者进行临床疗效评估和不良反应分析,同时随访患者疾病进展情况。结果 26例患者接受3个疗程以上Palonosetron-GDP方案化疗,其中6例完全缓解(完全缓解率23.1%),10例部分缓解(部分缓解率38.5%),总有效率61.5%。26例患者中位肿瘤进展时间为5.3月(95%CI:4.7～7.0)。主要不良反应为骨髓抑制,而非血液学毒性尤其是消化道不良反应轻微,其中化疗诱导恶心和呕吐不良反应Ⅰ级2例,Ⅱ级1例,没有Ⅲ～Ⅳ级呕吐反应。结论 Palonosetron-GDP方案是老年复发性非霍奇金淋巴瘤的有效挽救治疗方案,其中盐酸帕洛司琼能有效预防化疗诱导的消化道不良反应而不影响其疗效。Objective To evaluate the clinical efficacy and toxicity of paionosetron combined with GDP （Palonosetron-GDP） regimen in the treatment of elderly patients with relapsed non-Hodgkirs lymphoma. Methods A total of 28 elderly patients （age 60 years） with relapsed non-Hodgkin＇s lymphoma were enrolled in this pilot study. Responses and toxicities were evaluated for patients who received at least three courses of chemotherapy. Meanwhile, time to progression （TTP） was measured. Results From January 2009 to January 2012, 26 elderly patients with relapsed non-Hodgkin＇s lymphoma received at least three cycles of Palonosetron-GDP therapy and were evaluable for response analysis. Six patients a- chieved complete remission, while ten cases obtained partial response. The overall response rate was 61.5%. The median time to progression （TTP） was 5.3 months （95CI： 4.7-7.0 months）. Major toxicity of this regimen was myelosuppression, while other non-hematologic toxicities, especially gastrointestinal adverse effects were moderate in all the patients. Concerning chemotherapy induced nausea and vomiting （CINV）, no grade Ill - IV CINV occurred, although grade I and CINV were observed in two and one patients, respectively. Conclusion Palonosetron-GDP was an effective salvage therapeutic regimen for elderly patients with relapsed non-Hodgkin＇s lymphoma. Meanwhile, palonosetron might stro ngly prevent from chemotherapy-associated gastrointestinal toxicities.

关 键 词：非霍奇金淋巴瘤 老年 化疗 盐酸帕洛司琼 

分 类 号：R730.53[医药卫生—肿瘤]