P27蛋白在胞浆中的表达与鼻咽癌临床病理学特征的关系  

Cytoplasmic expression of P27 protein and its correlation with clinicopathologic features of nasopharyngeal carcinoma

作　　者：黄巍[1,2] 孙世珺[2] 叶亦菁[2] 方唯意[1] 

机构地区：[1]南方医科大学肿瘤研究所,广东广州510515 [2]中山市人民医院,广东中山528400

出　　处：《南方医科大学学报》2013年第6期882-884,共3页Journal of Southern Medical University

基　　金：国家自然科学基金委和广东省联合重点基金(U0732006)~~

摘　　要：目的评估p27蛋白在胞浆中表达与鼻咽癌患者临床病理学特征的关系。方法利用免疫组化检测P27蛋白在鼻咽癌组织与鼻咽组织之间的表达。利用统计学方法分析P27蛋白在鼻咽癌与鼻咽组织胞浆中表达差异以及P27蛋白在胞浆中表达与与鼻咽癌患者临床病理参数之间的相关性。结果免疫组化结果显示,P27蛋白是一个核浆表达蛋白。与正常鼻咽组织相比,P27蛋白在鼻咽癌组织胞浆中的表达明显下调(P=0.047),且下调表达与T分级(P=0.033)呈负相关。此外,P27蛋白在鼻咽癌组织胞浆中的表达与淋巴结转移和临床分期虽然无显著意义,但也展现了明显负相关趋势(P=0.157,P=0.090)。结论 P27蛋白在细胞胞浆中过低表达可能促进鼻咽癌的发生发展,且其可作为预测鼻咽癌患者预后的不利因素之一。Objective To evaluate the correlation of p27 protein expression in the cytoplasm with the clinicopathologic features of nasopharyngeal carcinoma （NPC）. Methods Immunohistochemistry was employed to examine P27 protein expression in the cytoplasm of NPC samples and nasopharyngeal （NP） tissue samples. The differential expression of P27 protein between NPCs and NPs and the correlation of cytoplasmic P27 protein expression with the clinicopathologic parameters of NPC patients was analyzed. Results Immunohistochemistry indicated significantly down-regulated t p27 protein expression in NPC tissues compared to that in NP tissues （P=0.047）. The reduction of P27 expression was inversely correlated with T classification of NPC （P=0.033）. Although cytoplasmic p27 protein expression was not significantly correlated with lymph node metastasis （P=0.157） or clinical stages of NPC （P=0.090）, an obvious trend of inverse correlations between them was noted. Conclusion Down-regulated cytoplasmic p27 protein expression may promote the carcinogenesis of NPC and can be an unfavorable prognostic factor for survival of NPC patients.

关 键 词：P27蛋白 鼻咽癌 胞浆表达 预后因子 

分 类 号：R739.63[医药卫生—肿瘤]