窄带成像联合自荧光支气管镜在肺癌诊断中的价值  

Combination of Narrow-band Imaging and Autofluorescence Imaging Videobronchoscopy in the Assessment of Lung Cancer

作　　者：陈众博[1] 虞亦鸣[1] 孙士芳[1] 马红映[1] 张巧丽[1] 吕丹[1] 王碧炯[1] 曹超[1] 丁群力[1] 邓在春[1] 

机构地区：[1]宁波大学医学院附属医院呼吸内科,宁波315020

出　　处：《中国肺癌杂志》2013年第6期299-302,共4页Chinese Journal of Lung Cancer

基　　金：宁波市社会科学发展专项基金课题(No.2012C50006)资助~~

摘　　要：背景与目的窄带成像(narrow-band imaging,NBI)与自荧光成像(autofluorescence imaging,AFI)是近几年临床诊断肺癌的支气管镜新技术。本研究旨在研究这两种技术的结合是否能提高肺癌诊断的敏感性和特异性。方法该项目共纳入137例疑似肺癌患者,所有患者的检查均基于Olympus Evis Lucera电子支气管镜系统,依次进行白光支气管镜(white light bronchoscopy,WLB)、窄带成像、自荧光成像检查,在每位患者镜下异常部位至少取3块组织送检。结果 WLB的敏感性、特异性分别为56.6%和62.5%;NBI成像的敏感性、特异性分别为71.3%和75.0%;AFI敏感性、特异性分别为82.2%和25.0%;NBI联合AFI的敏感性、特异性分别为94.6%和87.5%。NBI+AFI与AFI相比,两者敏感性及特异性均有统计学差异(P<0.01),与单用NBI相比,两者敏感性及特异性亦有统计学差异(P<0.05)。结论 NBI或AFI比WLB在肺癌诊断方面具有更好的敏感性,且联合使用NBI+AFI比其它任何一种单用技术具有更高的敏感性和特异性优势。Background and objective Narrow-band imaging （NBI） and autofluorescence imaging （AFI） are new bronchoscopy technologies that are important in lung cancer diagnosis. The aim of this study is to determine whether or not the combination of these two technologies can improve sensitivity and specificity of lung cancer diagnosis. Methods A total of 137 patients who manifested symptoms of lung cancer were investigated in this project. All of the examinations were performed based on an Olympus Evis Lucera bronchoscopy system. The patients were examined by white light bronchoscopy （WLB）, NBI and AFI. At least three biopsies from body parts visualized as lesions were obtained from each patient. Results WLB sensitivity and specificity were 56.6% and 62.5%, respectively. NBI sensitivity and specificity were 71.3% and 75.0%, respectively. AFI sensitivity and specificity were 82.2% and 25.0%, respectively. The sensitivity and the specificity of the combined NBI and AFI were 94.6% and 87.5%, respectively. The sensitivity and the specificity of the combined NBI and AFI were significantly higher than those of AFI alone （P〈0.01）. Likewise, the sensitivity and the specificity of the combined NBI and AFI were significantly higher than those of NBI alone （P〈0.05）. Conclusion NBI or AFI exhibited higher sensitivity of lung cancer diagnosis than WLB. Combined NBI and AFI also showed significantly higher sensitivity and specificity than NBI or AFI.

关 键 词：窄带成像 自荧光成像 肺肿瘤 诊断 

分 类 号：R734.2[医药卫生—肿瘤]