炎症小体与肿瘤发生的研究进展  

The inflammasome and tumorigenesis

作　　者：秦淼[1] 房静远[1] 

机构地区：[1]上海交通大学医学院附属仁济医院消化科,上海市消化疾病研究所,上海200001

出　　处：《肿瘤》2013年第6期556-560,共5页Tumor

摘　　要：炎症小体(inflammasome)是细胞内多聚体蛋白复合物,可调节白细胞介素1(interleukin-1,IL-1)家族促炎性细胞因子的成熟与释放,通过诱导caspase-1分子活化和细胞程序性死亡对外源性或内源性危险信号产生应答。作为炎性反应的中心环节,炎症小体不仅与各种炎性疾病有重要关联,而且对肿瘤的发生起着重要作用。本文就炎症小体的结构、活化信号、激活通路及其对肿瘤发生的作用等研究进展作一综述。The inflammasome is an intracellular multimeric protein complex that regulates the maturation and release of proinflammatory cytokines of the interleukin-1 （IL-1） family in response to exogenous or endogenous danger signals by the induction of activating caspase-1 molecule and the programmed cell death. As the center of the inflammatory response, the inflammasomes not only have a significant association with some inflammatory diseases, but also play a key role in tumorigenesis. This review is focused on the current progress in the structure, triggers and activation pathways of inflamasomes, as well as, their function in tumorigenesis.

关 键 词：肿瘤形成过程 炎症 白细胞介素1 半胱氨酸天冬氨酸蛋白酶1 炎症小体 NLRP3 

分 类 号：R730.231[医药卫生—肿瘤]