干细胞对称和不对称分裂在哺乳动物发育及肿瘤发生和发展中的研究进展  

Symmetric and asymmetric cell division in mammalian development and the initiation and progression of tumor

作　　者：张晨璐[1] 高维强[1] 朱鹤[1] 

机构地区：[1]上海交通大学医学院附属仁济医院临床干细胞中心及癌基因及相关基因国家重点实验室,上海200127

出　　处：《肿瘤》2013年第6期561-565,共5页Tumor

基　　金：国家重大科学研究计划973资助项目(编号:2012CB966800);国家自然科学基金重点资助项目(编号:81130038);国家自然科学基金资助项目(编号:81270627);上海市科委"浦江人才"资助项目;上海市科委"浦江人才"资助项目(编号:12PJ1406100);上海市卫生局重中之重临床医学重点学科;上海市教委重点学科建设资助项目(编号:J50208);王宽诚基金;上海市教委/上海市教育发展基金会"晨光计划"资助项目(编号:12CG16);上海市教委科研创新资助项目(编号:13YZ030);上海市高校优秀青年教师培养计划资助项目

摘　　要：干细胞具有自我更新和分化的潜力,在组织发育、再生和修复中起着重要的作用。干细胞通过对称和不对称分裂来维持自我更新和分化之间的平衡。一旦对称和不对称分裂的精密调控被破坏,不仅会导致干细胞数量的改变,还可能促使肿瘤的发生。因此阐明干细胞对称和不对称分裂的调控机制对于了解肿瘤的发生和发展、寻找治疗肿瘤的新方法十分重要。本文就干细胞不对称分裂在哺乳动物发育和肿瘤发生及发展中的研究进展作一综述。Stem cells play an essential role in the development, regeneration and repair of tissues due to their capability to reproduce themselves and differentiate. The balance of self-renewal and differentiation of stem cells is maintained through symmetric and asymmetric division. Once the intricate homeostasis of division pattern is disturbed, steady state of the stem cell numbers may be disrupted and consequently the development of neoplasms will be resulted in. Therefore, deciphering the molecular mechanism of controlling symmetric and asymmetric cell division is of importance to our understanding of tumor initiation and progression and the ultimate development of cure to cancer. This article reviews the research progress on asymmetric cell division in mammalian development and cancer biology.

关 键 词：肿瘤 干细胞 不对称细胞分裂 

分 类 号：R735.35[医药卫生—肿瘤]