Livin、Caspase-3在喉鳞状细胞癌组织中的表达  

Expressions of Livin and Caspase-3 in the Laryngeal squamous Cell Carcinoma Tissues

作　　者：张建中 蒋群 巴云鹏[2] 吕明栓[2] 

机构地区：[1]河源市人民医院耳鼻咽喉头颈外科,广东河源517000 [2]郑州大学第一附属医院耳鼻咽喉头颈外科,河南郑州450052

出　　处：《肿瘤基础与临床》2013年第3期188-191,共4页journal of basic and clinical oncology

摘　　要：目的研究Livin、Caspase-3在喉鳞状细胞癌(LSCC)组织中的表达以及与LSCC各临床病理参数的关系。方法采用免疫组织化学S-P法检测10例癌旁正常组织、61例LSCC组织中Livin、Caspase-3蛋白的表达。结果 LSCC组织中Livin蛋白表达高于癌旁正常组织,而Caspase-3蛋白表达低于癌旁正常组织(P均<0.05)。Livin、Caspase-3蛋白表达与LSCC临床分期、病理分化程度有关(P均<0.05)。在LSCC组织中,Livin蛋白与Caspase-3蛋白表达呈负相关(r=-0.387,P<0.05)。结论 Livin可通过抑制Caspase-3促进LSCC发生、发展。Objective To investigate the expressions of Livin and Caspase-3 in laryngeal squamous cell carcinoma （LSCC） tissues and the correlation with the clinicopathologic parameters of LSCC. Methods The expressions of Livin and Caspase-3 were examined by immunohistoehemistry S-P method in 10 cases of normal laryngeal tissues and 61 cases of LSCC tissues. Results Compared with the normal laryngeal tissues, the expression of Livin was higher, and the expression of Caspase-3 was lower in the LSCC tissues （ P 〈 0. 05 ）. The expressions of Livin and Caspase-3 were significantly associated with clinic stage and degree of differentiation （ P 〈 0.05 ）. In the LSCC tissues,the expression of Livin was negatively associated with Caspase-3 （γ = - 0. 387, P 〈 0.05 ）. Conclusion Livin may promote the genesis and development of LSCC through inhabiting lhe role of Caspase-3.

关 键 词：LIVIN CASPASE-3 喉鳞状细胞癌 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤] R730.23[医药卫生—临床医学]