三阴性乳腺癌临床病理特征及预后回顾性分析  

Triple Negative Breast Cancer Clinical and Pathological Features and Prognosis Retrospective Analysis

作　　者：赵夷[1] 胡婷嫣[1] 李锦成[1] 张韶光[1] 李雅勋[1] 

机构地区：[1]辽宁医学院附属第一医院乳腺外科,辽宁锦州121000

出　　处：《医学与哲学（B）》2013年第5期37-39,共3页Medicine & Philosophy(B)

摘　　要：回顾三阴性乳腺癌(TNBC)病例,进行临床病理特征对比及预后分析。收集2005年1月至2006年12月在我院经手术治疗,经病理组织学确诊,并可随访到的348例乳腺癌病例资料,研究其临床病理特征,分析预后。结果 TNBC多见于50岁以前未绝经女性,肿块>2cm(72.2%)比例高于非三阴性乳腺癌(non-TNBC)51.4%(P<0.05),复发转移率显著高于non-TNBC(P<0.05)。5年无病生存率(DFS),TNBC 62.8%低于non-TNBC 79.6%(P<0.05)。5年总生存率(OS),TNBC 73.6%低于non-TNBC 89.8%(P<0.05)。三阴性乳腺癌恶性程度高,转移复发率高,预后差,生存率低,其有效治疗方案需进一步研究。Review the data of triple negative breast cancer （TNBC） cases, and compared clinical and pathological teatures and prognosis. The clinical and pathological data of 348 cases of breast cancer patients treated by surgery from January 2005 to December 2006 in the First Affiliated Hospital of Liaoning Medical College, with histopathology confirmed, and can follow--up to study the clinical disease characteristics, analysis of prognosis. Compared with other breast cancer, tri- ple-negative breast cancer correlated with younger （〈50y） and tumor more than 2cm （72.2%） higher than non-triple negative breast cancer （non-TNBC） 51.4% （P〈0.05）. The recurrence rate was significantly higher than non-TNBC （P〈0.05）. The TNBC 5-year disease--free survival （DFS） 62.8% lower than the non- TNBC 5-year disease-free survival （DFS） 79.6% （P〈0.05）. The TNBC 5-year overall survival （OS）, 73.6% lower than non-TNBC 5-year o- verall survival （OS） was 89.8 % （P〈0.05）. Triple negative breast cancer, malignant high degree of metastasis and recur- rence rates compared with other types of breast cancer, poor prognosis, survival rate, effective treatment options require further study.

关 键 词：三阴性乳腺癌 临床病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]