血清尿酸水平与脑动脉狭窄的相关性研究  

Association between Uric Acid Level and Intracranial Artery Stenosis

作　　者：万鑫[1,2] 代成波[2] 曹裕民[2] 张雄[2] 张玉虎[2] 马桂贤[2] 王硕[2] 王丽娟[2] 

机构地区：[1]南方医科大学研究生学院,广州1510515 [2]广东省人民医院(广东省医学科学院)神经内科,广东省神经科学研究所

出　　处：《中国卒中杂志》2013年第6期437-442,共6页Chinese Journal of Stroke

基　　金：国家自然科学基金(30870863;30801219);广东省自然科学基金(8151008004000008);广东省科技计划项目(2009B030801251);广东省医学科研基金(A2010029;A2011039)

摘　　要：目的探讨血清尿酸与脑动脉狭窄之间的关系。方法连续入组2011年10月至2012年5月因缺血性脑血管病住院并行脑血管造影的患者509例,依据血管造影脑动脉狭窄部位及狭窄程度(≥50%)分为四组:颅内动脉狭窄组(198例)、颅外动脉狭窄组(107例)、脑动脉狭窄组(55例)及无脑动脉狭窄的对照组(149例)。分析患者临床资料及血尿酸水平与颅内动脉狭窄之间是否存在相关性。结果颅内动脉狭窄组血尿酸水平显著高于对照组(P<0.001),血尿酸异常患者的比例也显著高于对照组(χ2=7.388,P=0.007);将所有患者按血尿酸水平4分位分组,随着血尿酸水平的升高,颅内动脉狭窄的发生率逐渐增加(χ2=9.230,P=0.026)。Logistic回归分析显示,血尿酸水平升高是颅内动脉狭窄的独立危险因素之一[比值比(odds ratio,OR)1.005,P=0.001]。同样方法分析颅外动脉狭窄组与尿酸的关系未得到显著性结果。结论血尿酸水平升高与颅内动脉狭窄密切相关。Objective To discuss the association between uric acid （UA） and intracranial artery stenosis in patients with cerebrovascular disease. Methods Clinical data of 509 patients undergoing cerebral angiography were analyzed, and they were separated into four groups according to the findings of cerebral angiography：Intracranial artery stenosis group included 198 patients who had at least one intracranial large artery stenosis more than 50%;Extracranial artery stenosis group included 107 patients who had at least one extracranial large artery stenosis more than 50%; Cerebral artery stenosis group included 55 patients who had both intracranial and extracranial large artery stenosis more than 50%;and the control group included 149 patients who had none cerebral large artery stenosis. The relationship between UA level and intracranial artery stenosis was explored. Results The UA level of intracranial artery stenosis group was significantly higher than that of the control group （P〈0.001）, and the intracranial artery stenosis group had a marked higher rate of patients who had abnormal UA level （χ2=7.388, P=0.007）. The proportion of intracranial artery stenosis patients increased significantly with the increase of UA level （χ2=9.230, P=0.026）. Logistic regression analysis shows that UA level is one of the independent risk factors of intracranial artery stenosis （odds ratio[OR]=1.005, P=0.001）. The relationship between extracranial artery stenosis and UA was negative. Conclusion The elevated UA level correlates with intracranial artery stenosis and it is an underlying independent risk factor of intracranial artery stenosis.

关 键 词：颅内动脉狭窄 尿酸 脑血管造影 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]