国产氯屈膦酸二钠治疗恶性肿瘤骨转移疼痛  

Therapeutic Efficacy of Domestic and Imported Clodronate Disodium in the Treatment of Neoplastic Bone Metastasis Pain

作　　者：张沂平[1] 孙岩 孙琳[1] 陈玲[1] 

机构地区：[1]浙江省肿瘤医院,310022 [2]浙江省义乌市第三人民医院

出　　处：《浙江临床医学》2000年第6期377-378,共2页Zhejiang Clinical Medical Journal

摘　　要：目的观察国产氯屈膦酸二钠（洛屈）与进口同类药品骨膦治疗恶性肿瘤骨转移疼痛的疗效对比。方法８２例恶性肿瘤骨转移疼痛患者随机分为２组：洛屈组４２例，骨膦组４０例。洛屈组用３００ｍｇ溶于５００ｍｌ生理盐水中静脉滴注，每天一次，连续五天。结果洛屈组，止疼有效率为８３．３％，活动能力改善有效率６９．０％；骨膦抑制疼痛有效率８２．５％，活动能力改善有效率６７．５％。经医学统计学处理，两组疗效无显著性差异（ｐ＞０．０５）。结论国产氯屈膦酸二钠治疗恶性肿瘤骨转移疼痛疗效确切，无明显副反应，安全性好，可以替代进口同类药品。Objective To observe the therapeutic efficacy of domestic and imported Clodronate disodium in the treatment of neoplastic bone metastasis pain. Methods 82 neoplastic bony metastasis pain cases were divided at random into two groups: Clodronate disodium group (42 cases) and bone phosphine group (40 cases). Domestic Clodronate disodium 300 mg was intravenously given with 500 ml NS for five days followed by oral administration of the drug. Results The effective rate of the Clodronate disodium group was 83. 3% with 69. 0% improvement of physical movement while in the bone phosphine group, the effective rate was 82. 5% with 67. 5% improvement of the physical movement. No statistical difference was revealed between the two groups (P > 0. 05). Conclusion Do- mestic Clodronate disodium could effectively relieve the neoplastic bone metastasis pain with no evident side effects and could replace the imported pain killers for the treatment of neoplastic bone metastasis pains.

关 键 词：恶性肿瘤 肿瘤骨转移 疼痛 氯屈膦酸二钠 治疗 

分 类 号：R730.5[医药卫生—肿瘤]