直肠癌新辅助放化疗后病理完全缓解的相关研究进展  

Research progress on pathologic complete response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer

作　　者：彭海花[1] 游凯云[2] 高远红[2] 文碧秀[1] 

机构地区：[1]中山大学附属第一医院放射治疗科,广州510080 [2]华南肿瘤学国家重点实验室中山大学肿瘤防治中心放射治疗科

出　　处：《中华胃肠外科杂志》2013年第6期592-596,共5页Chinese Journal of Gastrointestinal Surgery

基　　金：国家自然科学基金（81071891）：广东省科技计划项目（2010B0807017）

摘　　要：局部晚期直肠癌标准的治疗方案为术前新辅助放化疗加手术的综合治疗。研究显示，直肠癌患者术前放化疗后达病理完全缓解者预后较好。尽管对这些患者的后续治疗方案有较大分歧，但已倾向于保守治疗而非根治性手术治疗。本文就局部晚期直肠癌术前新辅助放化疗后病理完全缓解的预后及预测等相关研究进展作一简要综述。Neoadjuvant chemoradiotherapy followed by surgery is the standard treatment for patients with locally advanced rectal cancer. Controversy on whether patients should receive radical surgery after pathological complete response （pCR） after neoadjuvant chemoradiotherapy has remained since pCR patients have shown favorable long-term outcome. Progress in multidisciplinary modalities has been made, including MRI, PET/CT imaging studies, genetic expression profiling, etc. The methods of predicting pCR response are inspiring. In this article, we review the methods for prediction and prognostic effect of pCR response when patients with locally advanced rectal cancer are treated with neoadjuvant chemoradiotherapy.

关 键 词：局部晚期直肠癌 新辅助治疗 病理完全缓解 

分 类 号：R735[医药卫生—肿瘤]