薏苡仁酯对人鼻咽癌细胞的放射增敏作用  

The Sensitizing Enhancement Effect of Coixenolide on the Irradiation to Human Nasopharyngeal Carcinoma Cell CNE-2Z

作　　者：胡笑克[1] 李毓[2] 吴棣华[2] 胡祖光[2] 梁昌盛[1] 

机构地区：[1]中山医科大学核医学教研室,广东广州510089 [2]广东省中医研究所,广东广州510405

出　　处：《中山医科大学学报》2000年第5期334-336,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

基　　金：广东省自然科学基金!(970 839);广东省中医药管理局资助!(9726 6 )

摘　　要：【目的】探讨薏苡仁酯 (CXL)对人鼻咽癌细胞CNE 2Z辐射效应的影响。【方法】以60 Co为放射源 ,采用微量细胞克隆形成法检测CNE 2Z对γ射线的敏感性。【结果】CXL使CNE 2Z的放射—存活曲线左移 ,Do 和Dq 值下降。不同浓度的CXL(10 -7～ 10 -6mol/L)使辐射剂量减少 7 45 %～ 17 31% (在D37水平 ) ,其增敏比 (SER) :Do 比值 1 11～ 1 46 ,Dq 比值1 0 2～ 1 11。【结论】CXL能提高CNE 2Z的放射敏感性。Objective To study the irradiation effect of coixenolide (CXL) to human nasopharyngeal carcinoma (NPC) cell line CNE-2Z. Methods Microclony formation assay was used in determining susceptibility of CNE-2Z to γ-ray ( 60 Co). Results CXL shifted the radiation dose-response curve to the left, with the decrease of D o and D q values. When different doses (10 -7 ～10 -6 mol/L) of CXL were added to culture system, radiation doses reduced by 7 45%～17 31% (at D 37 level), the sensitizing enhancement ratios (SER) were 1 11～1 46 and 1 02～1 11 at D o and D q level respectively. Conclusions CXL can increase the susceptibility of CNE-2Z to irradiation.

关 键 词：鼻咽癌细胞 放射疗法 放射增敏 薏苡仁酯 

分 类 号：R739.630.5[医药卫生—肿瘤] R730.55[医药卫生—临床医学]