老年大肠癌中PCNA和C-erbB-2的表达及意义  

PCNA and C-erbB-2 oncogene expression in senile large intestine cancer and its clinical significance

作　　者：于杰[1] 王丽萍[2] 王晓明[3] 

机构地区：[1]白求恩医科大学第二临床学院普外科,长春130041 [2]白求恩医科大学第一临床学院病理科 [3]白求恩医科大学基础组胚室

出　　处：《中国老年学杂志》2000年第5期285-286,共2页Chinese Journal of Gerontology

摘　　要：目的　检测 PCNA和 C- erb B- 2在老年大肠癌中的表达及其意义。方法　对 33例老年大肠癌的石蜡切片标本进行免疫组化染色。结果　 PCNA和 C- erb B- 2在 33例大肠癌中的阳性率分别为 66.7%和 60 .6% ;PCNA和 C- erb B- 2的表达与癌组织的分化程度及临床分期有明显相关性 (P<0 .0 1 ) ,淋巴结转移组中二者的表达明显高于无转移组 (P<0 .0 1 )。结论　 PCNA和 C- erb B- 2过高表达者预后不良 ,PCNA和 C- erb B- 2可作为判定老年大肠癌恶性程度及预后的有效指标。To examine the expression of PCNA and C erbB 2 oncogene in elderly patients with carcinoma of colon and its clinical significance.Methods 33 cases of paraffin embedded specimens were used for immunohistochemical study.Results The positive rates of PCNA and C erbB 2 oncogene were 66 7%(22/33) and 60 6%(20/33). The expression of PCNA and C erbB 2 were closely correlated with histodifferentiation and clinical staging (P<0 01) , the carcinomas with marked positive PCNA and C erbB 2 expression were more likely to metastasize to lymph nodes (P<0 01) .Conclusions Patients with over expression of PCNA and C erbB 2 oncogene showed poor prognosis of elderly colon cancer patients.

关 键 词：大肠癌 免疫组织化学 增殖细胞核抗原 C-ERBB-2 

分 类 号：R735.340.2[医药卫生—肿瘤]