儿童少年期精神分裂症患者及其一级亲属认知功能的对照研究  

Study of cognitive function in child-adolescent with schizophrenia and their first degree relatives

作　　者：王秀珍[1] 李坚[1] 陈桂兵[1] 辜卫红[2] 王建文[1] 陈刚[1] 孙太鹏 张莉[1] 

机构地区：[1]淮安市第三人民医院医学心理科,223001 [2]淮安市妇幼保健院保健科

出　　处：《临床精神医学杂志》2013年第3期167-170,共4页Journal of Clinical Psychiatry

基　　金：淮安市科技支撑计划(社会发展)(HAS2009008)

摘　　要：目的:探讨儿童少年期精神分裂症患者及其一级亲属的认知功能状况。方法:对40例儿童少年期精神分裂症患者(患者组)、80名父母(患者父母组)及22名同胞(患者同胞组)采用注意力测验、WMS-R-逻辑记忆、数字广度、连线测验A和B、词汇流畅性测验、Stroop色词测验及威斯康星卡片分类测验(WCST)评定其认知功能,并与59名健康儿童(健康儿童对照组)及其父母(健康儿童父母组)80名进行比较。结果:患者组除词汇流畅性测验以外,其他测验成绩差于健康儿童对照组;患者同胞组除数字顺背、词汇流畅性测验、连线测验-A、WCST正确应答数、WCST完成第1个分类应答数以外,其他测验成绩差于健康儿童对照组(P均<0.001);患者父母组除数字顺背、词汇流畅性测验、连线测验-A以外,其他测验成绩差于健康儿童父母组(P<0.01或P<0.001)。儿童精神分裂症患者与其父母在注意力测验、WMS-R-逻辑记忆、数字倒背、彩色文字阅读和彩色文字颜色阅读、WCST完成分数上呈正相关(r=0.350～0.615,P<0.05或P<0.001)。结论:儿童少年期精神分裂症患者及其一级亲属均存在广泛的认知功能缺陷,但患者的认知功能障碍更为严重。Objective：To explore the condition of the cognitive function in child-adolescent patients with schizophrenia and their first degree relatives. Method：Cognitive function was assessed using attention test, WMS-R-logical memory,digital span,trail making test （ TMT-A,B） ,verbal fluency test （ VFT） ,Stroop colorword test and Wisconsin card sorting test （ WCST） in 40 child-adolescent patients with schizophrenia （ case group） ,their 22 siblings （ case siblings group） and 80 parents （ case parents group） . The results were compared with 59 health children （ health children group ） and their 80 parents （ health children parents group ） . Results：Except VFT,the results of other tests in case group were lower than health children group. Except the forward digit span （ FDS） ,VFT,TAT-A,right cateory and the first completed response of WCST,the results of other tests in case sibling group were lower than health children group（ all P 0. 001） . Except FDS,VFT, TAT-A,the results of other tests in case parents group were lower than health children parents group; the discrepancy had statistical significance （ P 0. 01 or P 0. 001） . There were positive correlation between child-adolescent patients and their parents in the results of attention test,WMS-R-logical memory,backward digit span, Stroop-c,Stroop-cw and completed category of WCST （ r = 0. 350 ～ 0. 615,P 0. 05 or P 0. 001 ） . Conclusion：The child-adolescent patients with schizophrenia and their first degree relatives have general cognitive function deficits,but impairment in patients is more serious.

关 键 词：精神分裂症 儿童少年期 一级亲属 认知功能 

分 类 号：R749.94[医药卫生—神经病学与精神病学]