躯体形式障碍患者述情障碍与事件相关电位P300相关分析  

Study on relativity between alexithymia and event-related potential P300 in patients with somatoform disorder

作　　者：易峰[1] 梅佳[1] 毛静宇[1] 苏旭江[1] 汪艳[2] 

机构地区：[1]南京医科大学附属无锡精神卫生中心普通精神科,214151 [2]南京医科大学附属无锡精神卫生中心脑电生理室

出　　处：《临床精神医学杂志》2013年第3期178-180,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨躯体形式障碍患者述情障碍与事件相关电位P300的相关性。方法:随机将年龄18～65岁、符合中国精神障碍分类与诊断标准第3版躯体形式障碍诊断标准的患者42例作为研究组,选择40名健康者作为对照组。两组均进行多伦多述情障碍量表(TAS-20)测评和事件相关电位P300检测,并将结果加以分析比较。结果:与对照组相比,研究组CZ、PZ点N1、P2、N2、P3潜伏期明显延长(t=2.028～5.649;P<0.05或P<0.01),研究组CZ、PZ点N2、P3波幅明显降低(t=2.928～5.010;P<0.01)。研究组TAS-20总分及各因子分均高于对照组(t=2.322～9.656;P<0.05或P<0.01)。相关分析显示,研究组PZ点N2、P3潜伏期与TAS-20总分及各因子分正相关(r=0.32～0.46;P<0.01或P<0.05),PZ点N2、P3波幅与TAS-20总分及各因子分负相关(r=-0.31～-0.51;P<0.05或P<0.01)。结论:躯体形式障碍患者述情障碍的产生可能与认知功能受损有关。Objective：To investigate the relativity between alexithymia and event-related potential P300 in somatoform disorder patients. Method：42 patients （ among 18 ～ 65 years old） met with CCMD-3 for somatoform disorders criteria were recruited as research group. 40 normal healthy person were selected as control group. Toronto alexthymia scale-20 （ TAS-20） and P300 potentials were recorded with all the subjects. A comparison was made between the patients and the healthy subjects. Results：The latencies of CZ and PZ were significantly longer in patients with somatoform disorder than those in the normal controls（ t = 2. 028 ～ 5. 649, P 0. 05 or P 0. 01） ,the amplitudes of CZ and PZ were significantly lower in the patients （ t = 2. 928 ～ 5. 010,P 0. 01） . The three factors scores and the total score of TAS-20 test in patients with somatoform disorder were significantly higher than those in the normal controls（ t = 2. 322 ～ 9. 656,P 0. 05 or P 0. 01） . The latency of PZ was positively correlated with the factors scores and the total score of TAS-20（ r = 0. 32 ～ 0. 46, P 0. 05 or P 0. 01） and amplitude of PZ was negatively correlated with the factors scores and the total score of TAS-20 scores（ r = - 0. 31 ～ - 0. 51,P 0. 05 or P 0. 01 ） in patients with somatoform disorders. Conclusion：Patients with somatoform disorders presence of alexithymia and cognitive impairment,both of them have the correlation.

关 键 词：躯体形式障碍 述情障碍 认知功能 事件相关电位 

分 类 号：R749.7[医药卫生—神经病学与精神病学]