GnRHa对子宫肌瘤雌孕激素和表皮生长因子受体的影响  

Effects of GnRHa on ER, PR and Epidermal Growth Factor- Receptor in Uterine Leiomyoma

作　　者：李卫平[1] 严隽鸿[1] 林其德[1] 陈珠萍[1] 丁传伟[1] 高蓉奇 

机构地区：[1]上海第二医科大学仁济医院妇产科,上海200001

出　　处：《上海第二医科大学学报》2000年第5期425-427,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的探讨促性腺激素释放激素激动剂 (GnRHa)对子宫肌瘤内雌、孕激素受体 (ER、PR)、表皮生长因子受体 (EGF -R)的影响。　方法测定 1 3例子宫肌瘤患者经GnRHa治疗 3月后肌瘤内雌、孕激素受体和EGF -R水平 ,并以 2 8例未用药肌瘤作对照。　结果GnRHa治疗组肌瘤内ER、PR、EGF -R水平明显低于对照组。　结论GnRHa除减少肌瘤内ER、PR外 ,使肌瘤内EGFObjective To study the effect of GnRHa on ER、PR and EGF-R in uterine leiomyoma. Methods ER、PR and EGF-R in uterine leiomyoma in 13 patients (study group) who had been treated with GnRHa 150μg/d for 3 months before operation were compared with 28 patients (control group) in whom no GnRHa was taken. Results The ER, PR and EGF-R in the GnRHa treated patients were significantly lower than those in the control group. Conclusion In addition to decreasing the ER and PR content, GnRHa can reduce the EGF-R level in leiomyoma. This may be an important therapeutic mechanism of GnRHa.

关 键 词：雌激素受体 孕激素受体 子宫肌瘤 EGF-R GNRHA 

分 类 号：R737.33[医药卫生—肿瘤]