氨磺必利对首发精神分裂症患者认知功能的影响  

Effects of amisulpride on the cognitive function in first-episode schizophrenia patients

作　　者：黄继伟 李林[2] 吕维忠 韩自力[3] 

机构地区：[1]河南省信阳市精神病院,信阳464000 [2]解放军第91医院 [3]中山大学附属第三医院

出　　处：《中华行为医学与脑科学杂志》2013年第6期497-499,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的 探讨氨磺必利对首发精神分裂症患者认知功能的影响.方法 对64例首发精神分裂症患者,按抛币法随机分为两组,分别给予氨磺必利和利培酮治疗,疗程12周.在治疗前及治疗后2,4,8,12周末分别采用阳性与阴性症状量表（PANSS）,副反应量表（TESS）评定疗效和不良反应；治疗前后采用韦氏成人记忆量表（WMS-RC）,威斯康星卡片分类测验（WCST）,连线测验A和B等进行认知功能评定,并与正常对照组比较.结果 治疗12周后,氨磺必利组和利培酮组的PANSS总分分别为（44.7±6.7）分,（45.2±7.4）分,与治疗前比较均差异有统计学意义（P＜0.01）,两组间比较差异无统计学意义（P＞0.05）.治疗前,两患者组WMS-RC的长时记忆,短时记忆,瞬时记忆,记忆商（QM）,WCST的持续错误数（Rpe）,持续应答数（Rp）,完成第一个分类所需应答数（R1st）和完成分类数（Cc）及TAT-A,TAT-B受损明显,与对照组比较均差异有统计学意义（P＜0.05或＜0.01）.治疗12周后,患者组WMS-RC的再认,联想,理解,背数,记忆商（QM）,及TAT-A,TAT-B与治疗前比较均明显改善接近正常（均P＞0.05）；患者组WCST的Rpe,Rp,R1st,Cc评分[氨磺必利组分别为（20.63 ±13.06）分,（28.75±15.72）分,（43.17±22.13）分,（3.62±2.21）分.利培酮组分别为（20.41±13.82）分,（29.31±16.12）分,（42.78±21.42）分,（3.67±2.32）分.]与正常对照组比较均差异有统计学意义（均P＜0.05）.两组间治疗前后认知功能各项评分比较无统计学意义（均P＞0.05）.结论 氨磺必利治疗精神分裂症疗效肯定,与利培酮相当,对精神分裂症的认知功能缺陷有改善作用.Objective To explore the effects of amisulpride on the cognitive function in first-episode schizophrenia patients.Methods 64 patients in first-episode schizophrenia were divided into two groups randomly according to the method of tossing a coin,then treated with amisulpride or risperidone respectively for 12 weeks.The efficacy and adverse effect were evaluated with positive and negative scale （PANSS） and treatment emergent side effect scale （TESS） before treatment and after treatment for 2 weeks,4 weeks,8 weeks,12 weeks.Before and after treatment for 12 weeks,cognitive function of all the patients was blindly evaluated with Wechsler Scale-revised China （WMS-RC）,Wisconsin Card Sorting Test（WCST） and Trail Making test A and B.Results After 12-week treatment,statistical difference was found in amisulpride（44.7 ± 6.7） and risperidone （45.2 ± 7.4） groups （P 〈 0.01）.But no statistical difference was found between the two groups （P 〉 0.05）.The cognitive function in firstepisode schizophrenia was damaged obviously.In two groups,the scores in recognize,association,comprehend,back a few and MQ of WMS and TAT-A,TAT-B were improved significantly after treatment for 12 weeks （P 〉 0.05）.These items of WCST were improved more remarkably than baseline （amisulpride （20.63 ± 13.06）,（28.75 ± 15.72）,（43.17 ±22.13）,（3.62 ±2.21）,P〈0.05; risperidone（20.41 ±13.82）,（29.31 ± 16.12）,（42.78 ± 21.42）,（3.67 ± 2.32）,P 〈 0.05）.The improvement in the scores of WCST were statistical difference compared with control group（P 〈 0.05）.But statistical difference was no found between the two groups （P 〉 0.05）.Conclusion The study shows that the cognitive dysfunction in first-episode schizophrenia can be improved by amisulpride,and the efficacy was similar with risperidone.

关 键 词：氨磺必利 利培酮 精神分裂症 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]