基于酪氨酸端基的ACE三肽抑制剂定量构效关系研究  

Studies on the structure-activity relationship of ACE inhibitory tri-peptides with tyrosine as terminal

作　　者：曾威[1] 黄国栋[1] 吴文娟[1] 张荣[1] 

机构地区：[1]广东药学院药科学院物理化学教研室,广州510006

出　　处：《原子与分子物理学报》2013年第3期463-470,共8页Journal of Atomic and Molecular Physics

基　　金：国家自然科学基金(20903026);广东省高等学校人才引进专项资金(2011);广东省自然科学基金(S2011010002483)

摘　　要：固定酪氨酸为端基对ACE三肽抑制剂进行构效关系研究,采用多元线性回归方法,基于不同描述符建立模型,比较模型的可靠性和准确性.结果表明Z描述子建立的模型最好.定量构效关系研究表明ACE抑制三肽第二位氨基酸的电性参数是抑制活性的最大影响因素.The quantitative structure-activity relationship of angiotensin converting enzyme （ACE） inhib- itory tri-peptide with tyrosine as terminal has been studied in the paper. Three different amino acids de- scriptors were used to establish the model by using multiple linear regression method. Z-scales descrip- tors were proved to be the best one. It is found that the electronic properties of the second amino acids is the dominant influence for the activities of the ACE inhibitory tripeptide.

关 键 词：酪氨酸 ACE三肽抑制剂 定量构效关系 

分 类 号：O641[理学—物理化学]