片状水凝胶药物载体释药机理的研究  

The Study on Release Mechanism of Hydrogel Piece as Drug Carrier

作　　者：阚文涛[1] 李欣[2] 罗顺忠[1] 胡睿[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,绵阳621900 [2]哈尔滨工业大学化学系,哈尔滨150001

出　　处：《材料导报（纳米与新材料专辑）》2013年第1期221-223,共3页

基　　金：国家自然科学基金(50878061);城市水资源与环境国家重点实验室课题(ESK200801)

摘　　要：解释了包埋5-氟尿嘧啶药物的片状水凝胶载体在模拟体液中的释药机理,通过分析药物在凝胶中扩散所遵循的数学规律得出结论:当药物的释放过程为水凝胶的松弛控制,以溶剂的移动为主要影响因素时,药物将从水凝胶载体中匀速释放。并以实验验证所得结论,实验结果与由数学分析得出的结论相符。The mechanism of drug release process from dry hydrogel pieces containing 5-fluorouracil in simula- ted body fluid has been explained. Conclusions have been drawn through analysis on mathematical rule which the dif- fusion of drug in hydrogels follows. When drug release is controlled by hydrogel relaxation, and the movement of sol- vent is the key factor, drug may release from the hydrogels at constant rate. An experiment has been performed to test the conclusions, whose outcomes are consistent with the conclusions drawn from the mathematical analysis.

关 键 词：药物释放机理 数学分析 水凝胶 5-氟尿嘧啶 载体 

分 类 号：O632.52[理学—高分子化学]