大肠癌中p185^(erbB2)、p21^(ras)、p53的表达及其临床病理意义  

Expressions of c-erbB-2、ras and p53 Oncoproteins in Colorectal Carcinoma and Its Clinicopathological Value

作　　者：李晓霞[1] 李奕[1] 肖培[1] 张菁茹[1] 

机构地区：[1]辽宁省肿瘤医院,110042

出　　处：《实用癌症杂志》2000年第5期478-480,共3页The Practical Journal of Cancer

摘　　要：目的　研究大肠癌中p185 erbB2 、p2 1ras、p5 3的表达及其临床病理意义。方法　采用S P法检测 80例大肠癌组织中p185 erbB2 、p2 1ras、p5 3的表达。 结果　大肠癌原发病灶中 p185 erbB2 、p2 1ras、p5 3的阳性表达率分别为 5 8.8%、71.3 %及 5 3 .8%。癌组织同时有 2种以上蛋白表达者占 6 3 .7% (5 1/80 ) ,有 3种蛋白同时表达者占 30 % (2 4/80 )。p185 erbB2 的阳性表达与肿瘤组织学类型有关 ;p2 1ras的阳性表达与肿瘤组织学类型、浸润深度、淋巴结转移有关 ;p5 3的阳性表达与临床病理指标无相关性。 结论　c erbB 2、p2 1ras及 p5 3可能与大肠癌的发生有关 ,在大肠癌的发生中可能起协同作用 。Objective To investigate the expression of c-erbB-2,ras and p53 gene proteins in colorectol carcinoma and its clinicopathological value.Methods Immunohistochemical techniques(SP method) were used for detection of the oncogene protein products p185,p21 and p53 in 80 cases of colorectal carcinoma.Results The positive rates of p185,p21 and p53 expression were 58.8%, 71.3% and 53.8% respectively.Overexpressions of two or three proteins occurred in 63.7% of the 80 cases.Overexpression of p185 showed a positive correlation with histologic type;Overexpression of p21 showed a positive correlation with histologic type,depth of invasion and lymph node metastasis.Overexpression of p53 was not correlated with clinicopathologic parameters.Conclusion p185,p21 and p53 play a combined role in colorectal carcinoma occurring.There was no significant association between their overexpressions and prognosis in colorectal carcinoma.

关 键 词：p185^erbB2 P21^RAS 大肠癌 免疫组织化学 病理 

分 类 号：R735.340.2[医药卫生—肿瘤]