肺癌p53蛋白和增殖细胞核抗原的检测及其意义  

Expression and Significance of p53 Protein and PCNA in Primary Lung Cancer

作　　者：吕福东[1] 张海青[1] 黄志英[1] 张丽丽 

机构地区：[1]北京市结核病胸部肿瘤研究所,101149

出　　处：《实用癌症杂志》2000年第5期485-486,共2页The Practical Journal of Cancer

摘　　要：目的　探讨p5 3蛋白、PCNA联合表达在临床中的意义。方法　应用免疫组织化学S P法检测 10 1例肺癌组织中p5 3蛋白、PCNA的表达。 结果　p5 3蛋白在肺癌组织中有较高的表达 ,总阳性率为 5 9.4% (6 0 /10 1)。p5 3蛋白表达与肿瘤分化程度呈正相关 (P <0 .0 5 ) ,而与肺癌患者的生存期呈负相关 (P <0 .0 1)。p5 3蛋白表达与PCNA染色密切相关 (P <0 .0 5 )。 结论　p5 3蛋白表达可作为判断肺癌患者预后的 1个重要参考指标。Objective To investigate the relationship between p53 protein and proliferating cell nuclear antigen(PCNA) and the clinical significance in primary lung cancer.Methods S-P immunohistochemistry method was used in 101 cases of primary lung cancer tissue.Results Abnomalities in p53 expression were found,the positive ratios was 59.4%(60/101).p53 overexpression were associated with tumor grading and survival time( P <0.05).A significantly higher PCNA expression score was found in the p53-positive samples( P <0.05).Conclusion This finding suggests that overexpression of p53 could be used as an independent prognostic factor for the patients with lung cancer.

关 键 词：P53蛋白 增殖细胞核抗原 免疫组织化学 肺肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]