梗阻性黄疸大鼠胃电及胃运动的实验研究  

Gastric Electric Activity and Motility in Obstructive Jaundice Rat

作　　者：李非[1] 孙家邦[1] 刘爽[1] 蔡伟[1] 刘素梅[2] 曲瑞瑶[2] 曾文红[2] 曲柏林[2] 

机构地区：[1]首都医科大学宣武医院普外科 [2]首都医科大学生理学教研室

出　　处：《首都医科大学学报》2000年第1期46-48,共3页Journal of Capital Medical University

摘　　要：为探讨梗阻性黄疸大鼠及其合并应激时胃电波和胃运动的变化 ,用SD大鼠建立梗阻性黄疸和约束水浸应激模型。实验动物共分 4组 :假手术对照组、梗阻性黄疸组、假手术应激组和梗阻性黄疸应激组 ,同步记录 4组大鼠的胃电波和胃运动波。结果发现 :梗阻性黄疸大鼠胃电慢波频率加快、胃运动频率显著加快 ,并伴有高频率的簇状收缩 ;受到应激刺激的黄疸大鼠运动振幅升高 ,频率下降 ,但同时仍有高频率的簇状收缩。提示 :梗阻性黄疸及其合并应激时胃电慢波节律紊乱 ,并出现高频率的簇状收缩可能是导致胃蠕动功能障碍的生理基础。The purpose of this study was to determine the gastric electrical activity and motility in obstructive jaundice and stress rat. 41 adult SD rats were used and divided into 4 groups, i.e. sham operation , obstructive jaundice, sham operation stress and obstructive jaundice with stress group. The gastric electrical activity and motility were recorded at same time. Gastric electrical slow wave frequence and motive frequence were increased significantly in obstructive jaundice rat. After cold restrain stress, the amplitute of motility was increased and frequency was decreased obviously. The clustered contractions could be observed in the obstructive jaundice rat. The result suggested that gastric dysrythmias and high frequent clustered contraction may be physical basis of gastric motor dysfunction in obstructive jaundice and stress.

关 键 词：梗阻性黄疸 胃电 胃运动 实验研究 

分 类 号：R575[医药卫生—消化系统]